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SNRIs

312 people credit SNRIs as one reason they got better overall (153 with ME/CFS, 159 with long COVID).

Everyone · 2,061 people

All 2,061 who tried one of its treatments

How it went for everyone who tried one of its treatments

Helped means they said it helped with what they took it for, which may be one symptom and not the illness. Each person counts once: someone who tried several of these treatments is split equally across those they said how it went for.

55%
helped
938 of 1,692
12%
no change
197 of 1,692
33%
got worse
557 of 1,692

Shares are out of the 1,692 people who said how it went for at least one of them, each counted once, the parts rounded to whole people. 369 more tried one or credit the approach without saying how it went.

Show as a table
How it wentPeopleShare
Helped a lot17610%
Helped76245%
No change19712%
Worse46728%
Much worse905%

Everyone · 312 people

312 who credit it

Among the 312 who credit it with their improvement, here’s how they are now

Credit it means they say it’s one reason they got better.

16%
recovered or near normal
51 of 312
69%
much or somewhat better
215 of 312
15%
relapsed
46 of 312

Where each person was at the end of their story, or in their latest post that says how they are, compared with their worst point.

Show as a table
Outcome describedPeopleShare
Recovered93%
Near normal4213%
Much better10233%
Somewhat better11336%
Relapsed4615%

Did it last?

  • 25 of 312 said the benefit of a treatment in this approach wore off (16 of them among the 46 who relapsed).
  • 165 of 312 say they still need to keep doing something (not always one in this approach) to stay well.

Read from what people wrote, and the more someone wrote, the more likely they are to mention it. Some people stop posting before saying, so the real number may be higher.

312 who credit it

By how ill people were

Only the 312 who credit this approach, so people it didn’t help or made worse aren’t here. How they are now is their outcome overall.

Severity at worstHow they are nownRecovered or near normal
Mild4730%
Moderate9510%
Severe11214%
Very severe1811%
Not stated4023%
Show as a table
At worstOutcomePeopleShare
MildRecovered1 of 472%
MildNear normal13 of 4728%
MildMuch better3 of 476%
MildSomewhat better26 of 4756%
MildRelapsed4 of 478%
ModerateRecovered5 of 955%
ModerateNear normal5 of 955%
ModerateMuch better36 of 9538%
ModerateSomewhat better34 of 9536%
ModerateRelapsed15 of 9516%
SevereRecovered2 of 1122%
SevereNear normal14 of 11212%
SevereMuch better47 of 11242%
SevereSomewhat better31 of 11228%
SevereRelapsed18 of 11216%
Very severeNear normal2 of 1811%
Very severeMuch better8 of 1844%
Very severeSomewhat better3 of 1817%
Very severeRelapsed5 of 1828%
Not statedRecovered1 of 403%
Not statedNear normal8 of 4020%
Not statedMuch better8 of 4020%
Not statedSomewhat better19 of 4047%
Not statedRelapsed4 of 4010%

Treatments in this approach

Bar: how it went for everyone on the site who tried it and said so. Recovered and Faded: of the people here who credit it.

The bar (How it went) and the line under each name are among everyone on the site who tried it and said how it went, the same numbers as on each treatment’s own page. Recovered and Faded are among the people here who credit it. Grey numbers rest on fewer than 10 people; a faded share in red is a third or more.

Fewer than 3 people here credit these, so they aren’t ranked: Levomilnacipran (Fetzima).

Everyone · 312 people

20 of the 312 people

See all 312 stories
  • Housebound with ME/CFS and brain fog, now much better with pacing and antihistamines

    Much better Lagoon 80616 ME/CFS Moderate at worstIll 6.5 years before improving or writing reddit.com Oct 2026

    Ill from March 2020, they were housebound with POTS, brain fog and PEM early on, and in May 2023 said treatments had taken them from about 30% to 70% of normal. Blood thinners, guanfacine, antihistamines, continuous progesterone, pacing and other medications…

  • Housebound with long COVID, now much better and back at work after rest and acupuncture

    Much better Spruce 30711 Long COVID Severe at worstIll 2.5 years before improving or writing reddit.com Oct 2026

    An Australian academic in their forties got long COVID in May 2024 after a third infection: brain fog first, then crippling fatigue that left them housebound and crashing daily for months. Rest, time and treatments including acupuncture greatly improved…

  • Long COVID brain fog, fatigue and POTS, now much better with pacing and compression

    Much better Vale 64877 Long COVID Moderate at worstIll 17 months before improving or writing reddit.com Oct 2026

    A retired Northern California woman got long COVID in Italy in October 2024, with brain fog, fatigue, tinnitus and gut trouble; POTS was diagnosed later. Low-dose naltrexone, bupropion, acupuncture, osteopathy, pacing, salt and compression brought slow…

  • Largely housebound with ME/CFS, somewhat better with LDN and cannabis

    Somewhat better Tide 27404 ME/CFS Severe at worstIll 12 years before improving or writing reddit.com Oct 2026

    Ill at 26 with CFS around 2013, this Reddit user has spent years largely housebound with pain, nausea, gastroparesis and suicidal thoughts. LDN, gabapentin, cannabis, Valcyte and Iberogast helped some symptoms; he remains housebound, with good and bad days…

  • Mostly housebound with ME/CFS fatigue and brain fog, somewhat better; cane helps standing

    Somewhat better Orchid 23158 ME/CFS Moderate at worstIll 4.5 years before improving or writing reddit.com Oct 2026

    Orchid 23158 linked an ME-like illness to a late-2021 cycling accident and concussion, though unsure whether COVID or concussion triggered it, and had long struggled with chronic fatigue. Years on they were still undiagnosed and mostly housebound with…

  • Bedbound with ME/CFS, now much better and working part-time after rest and LDN

    Much better Starling 76199 ME/CFS Very severe at worstIll 9 years before improving or writing reddit.com Oct 2026

    Diagnosed with ME/CFS in 2017, they were very severe and bedbound for about two years around 2024, unable to eat, sit up or tolerate light and sound. They credit total rest, low-dose naltrexone (up to 4.5 mg twice daily), Effexor, a vagus nerve device,…

  • Moderate ME/CFS back to mild with whole-food diet, then housebound after reinfection

    Relapsed Beech 74647 ME/CFS Moderate at worst reddit.com Oct 2026

    Beech 74647, in the UK, developed very mild ME after autism burnout and a physical job, later reaching mild. COVID in 2022 pushed them to moderate; a whole-food diet, a cleaner, work adjustments and later duloxetine with reduced hours brought them back to…

  • Long COVID fatigue and brain fog: clomipramine helped, then symptoms returned

    Relapsed Sequoia 65682 Long COVID Ill 4.5 years before improving or writing reddit.com Oct 2026

    Long COVID since June 2022 with fatigue, brain fog, headaches, anxiety and low mood, plus severe sleep apnoea on CPAP. Clomipramine with amisulpride helped for ten months but symptoms returned after stopping; venlafaxine 75 mg with amisulpride helped for a…

  • ME/CFS: a year very severely ill, decades mostly mild, now worse again, rest credited

    Relapsed Acorn 82743 ME/CFS Very severe at worstIll 40 years before improving or writing reddit.com Oct 2026

    Has had ME/CFS for four decades: a year very severely ill, then decades mostly mild, with long severe crashes that resolved with rest alone; she stopped working. She credited rest, not treatment; two COVID vaccines put her in bed nine months with neuropathy,…

  • Chronic pain and fatigue, somewhat better on Effexor and LDN

    Somewhat better Beech 68650 ME/CFS reddit.com Oct 2026

    Beech 68650 writes in ME/CFS forums about chronic pain and fatigue. Switching from an SSRI to the SNRI Effexor for pain and fatigue made a load of difference, and they say they could not live without LDN, which they must take in the morning. Low-dose Abilify…

  • ME/CFS needing a walker and crashing, somewhat better with pacing and avoiding illness

    Somewhat better Cedar 15127 ME/CFS Mild at worst reddit.com Oct 2026

    An Australian redditor with ME/CFS described being mild, moderate when flaring, needing a walker for a weekly day at university and crashing for three days afterwards. They credited pacing and avoiding illness for a noticeable improvement over two years; a…

  • Fully bedridden with severe ME/CFS and POTS; much better now, propranolol cleared POTS

    Much better Gull 10993 ME/CFS Severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    Mild ME/CFS began in 2020 after back-to-back mono and COVID. A NAC+ drip later left them severe and fully bedridden with severe POTS and a resting heart rate of 120-160. Extended-release propranolol 60 mg for three to four months cleared the POTS completely,…

  • Moderate long COVID after a crash, improved then relapsed, midodrine helped blood flow

    Relapsed Birch 13033 Long COVID Moderate at worst reddit.com Oct 2026

    Birch 13033, a 43-year-old man with long COVID, was mild until his daughter was born, then crashed to moderate in the newborn months and stayed there, now on half-time medical leave with a part-time nanny. Guanfacine sharpened his thinking but worsened his…

  • Bedridden with long COVID three months, now somewhat better, credits nicotine patches

    Somewhat better Bluebell 60696 Long COVID Severe at worstIll 4 years before improving or writing reddit.com Oct 2026

    A trans woman who fell ill with a severe COVID infection in 2022 was bedridden and off work for three months and nearly died. Nicotine patches cleared her brain fog within an hour, and she later credited clenbuterol, venlafaxine, cimetidine, NAC and…

  • ME/CFS slowly worsening, worse again after Covid, tried Modafinil and acyclovir

    Relapsed Sandpiper 47979 ME/CFS Moderate at worstIll 14 years before improving or writing reddit.com Oct 2026

    Man who has had ME/CFS since 2009 after H1N1, initially mild and slowly worsening, with a faster decline and more frequent, severe crashes after Covid in 2020. He uses a self-designed mix of treatments including Modafinil, acyclovir, anti-inflammatories,…

  • Mostly bedbound with long COVID, now much better with antihistamines and low-histamine diet

    Much better Lynx 15587 Long COVID Severe at worstIll 6 months before improving or writing reddit.com Oct 2026

    Lynx 15587, working overseas for an American company, developed long COVID after a December 2023 infection and was mostly bed bound for the first two months. Daily H1/H2 antihistamines, a low-histamine diet, rest and supplements made her functional enough to…

  • Moderate ME/CFS with POTS and pain, somewhat better with Effexor and IV fluids

    Somewhat better Flint 74188 ME/CFS Moderate at worst reddit.com Oct 2026

    Flint 74188 reported moderate CFS with POTS, PEM, pain, migraines and gut motility problems, plus severe treatment-resistant depression dating from before the CFS. After Prozac made them feel worse, Effexor helped stabilise mood, with Wellbutrin helping some…

  • ME/CFS exhaustion, brain fog, improved for four months with breath-holding, then relapsed

    Relapsed Creek 26448 ME/CFS Moderate at worstIll 11 years before improving or writing reddit.com Oct 2026

    He fell ill in 2015 with exhaustion and unrefreshing sleep, followed by brain fog a year later, and was diagnosed with ME/CFS, fibromyalgia and mild sleep apnoea; CPAP gave no benefit. In 2022, during a breath-holding course, his symptoms vanished overnight…

  • Severe ME/CFS, now milder end of moderate after pacing

    Much better Creek 98736 ME/CFS Severe at worstIll 2.5 years before improving or writing reddit.com Oct 2026

    Creek 98736 fell ill overnight in January 2021 and was severe to very severe for about two and a half years, sleeping 21 hours a day and unable to write or speak at times. Around her May 2023 ME diagnosis she began pacing and stopped antidepressants that had…

  • Bedbound with ME/CFS, now housebound, credits pacing and CoQ10

    Somewhat better Crest 79083 ME/CFS Severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    Crest 79083 fell ill with ME/CFS in 2016 and declined over years of pushing to a bedbound severe state by 2022, able to look at screens only briefly. Careful pacing raised their baseline from bedbound to housebound; daily 200 mg ubiquinol CoQ10 and…

The newest 20 people who credit SNRIs.

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New recovery stories and data-driven research on ME/CFS and long COVID. Ideas worth considering, and the evidence behind them.

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