Long COVID somewhat better after low-dose naltrexone despite severe flares
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Aug 2026
In their words
- Condition: Long COVID
r/covidlonghaulers
In context ↗ - Now: Somewhat better
at this dosage I feel the best I have yet and I am in such a better condition now than I was before starting.
In context ↗
Summary
Posting in a long-COVID community, Glade 73937 said low-dose naltrexone left them in a much better condition over ten months. They began at 0.5 mg, switched the filler to ginger and dropped to 0.25 mg, then titrated to 1.5 mg, their best yet. Starting the drug and each dose change caused a severe MCAS flare lasting days to weeks, but they pushed on and credit LDN.
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What they tried
What they credit
Their words about each treatment
- LDN · Helped
I’m at 1.5 now and it’s been 10 months. There’s been ups and downs but at this dosage I feel the best I have yet and I am in such a better condition now than I was before starting.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | long COVID, worse before low-dose naltrexoneI am in such a better condition now than I was before starting.In context ↗ | |
| — | horrible MCAS flare at the start and after each dose adjustmentit caused me to have a horrible MCAS flare up at first and anytime I’d adjust dosage for days to weeks afterIn context ↗ | Low-dose naltrexone |
| 2026-08-11 | best they have felt, at 1.5 mg after ten monthsat this dosage I feel the best I have yet and I am in such a better condition now than I was before startingIn context ↗ | Low-dose naltrexone |
Adverse events
- Low-dose naltrexone“it caused me to have a horrible MCAS flare up at first and anytime I’d adjust dosage for days to weeks after, even with ginger” In context ↗ Autoimmune or inflammatory flare
Symptoms mentioned
Their words about their symptoms
- Mast cell (MCAS) & allergies
it caused me to have a horrible MCAS flare up at first and anytime I’d adjust dosage for days to weeks after, even with ginger
In context ↗
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