ME/CFS
Outcome unclear
ME/CFS with dysautonomia, tried Plaquenil and a biologic, no lasting change
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
it never touched my ME symptoms one way or the other
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A Reddit user with ME and dysautonomia wrote that Plaquenil took a couple of months before they noticed it doing anything, but that it never touched their ME symptoms either way. Their first biologic made them flare badly for a few weeks before settling. Dysautonomia stayed about the same throughout, perhaps slightly worse during the adjustment windows. They did not describe any lasting change in their ME state.
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What they tried
Also tried
Plaquenil· HelpedBiologics· Worse
Their words about each treatment
- Plaquenil · Helped
Plaquenil took a couple months before I noticed it doing anything but it never touched my ME symptoms one way or the other.
In context ↗ - Biologics · Worse
Biologics were a different story, first one made me flare like crazy for a few weeks then settled.
In context ↗
Adverse events
- “first one made me flare like crazy for a few weeks then settled.” In context ↗ Autoimmune or inflammatory flare
- “Dysautonomia stayed about the same throughout, maybe slightly worse during the adjustment windows.” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
Dysautonomia stayed about the same throughout, maybe slightly worse during the adjustment windows.
In context ↗