ME/CFS
Outcome unclear
ME/CFS: very small daily amitriptyline gave some success with executive functioning
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Sep 2025
In their words
- Condition: ME/CFS
with CFS you are working hard ALL the time to constantly inhibit what you want to so you don't overdo it
In context ↗
Summary
A person with ME/CFS reported needing rest days after stimulant medication and said bupropion (Wellbutrin) caused a massive ongoing crash within days. A very small 5 mg daily dose of amitriptyline gave some success with executive functioning and was tolerable every day. They also advised low-dose naltrexone, electrolytes and aggressive rest at the first sign of overdoing it. Onset and overall function were not described.
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What they tried
Also tried
amitryptelene· Helpedwellbutrin· Much worseLDN· Not saidelectrolytes· Not saidaggressive resting· Not saidanti inflammatories· Not saidsleep aid· Not saidstimulant medication· Not said
Their words about each treatment
- LDN · Not said
LDN, electrolytes and get in bed and aggressively rest as soon as you realise you overdid it.
In context ↗ - aggressive resting · Not said
aggressive resting is key
In context ↗ - anti inflammatories · Not said
Sometimes anti inflammatories can help with the muscle pain
In context ↗ - sleep aid · Not said
Taking a sleep aid can help as well.
In context ↗ - amitryptelene · Helped
I am having some success with executive functioning taking 5mg amitryptelene every day.
In context ↗ - stimulant medication · Not said
whereas I can't take my stimulant medication everyday as I need rest days after
In context ↗ - wellbutrin · Much worse
I also couldn't take wellbutrin at all as it just led to a massive ongoing crash a couple days in.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| onset | ME/CFS onset (date not given)with CFS you are working hard ALL the time to constantly inhibit what you want to so you don't overdo itIn context ↗ |
| 2025-09-10 | massive ongoing crash after starting Wellbutrin (bupropion)I also couldn't take wellbutrin at all as it just led to a massive ongoing crash a couple days in.In context ↗ |
| 2025-09-10 | some success with executive functioning on daily amitriptylineI am having some success with executive functioning taking 5mg amitryptelene every day.In context ↗ |
| 2025-09-10 | tolerating a very small daily amitriptyline dose; stimulants only some days with rest days after5mg of amitryptelene is a very small dose that i can tolerate everyday.In context ↗ |
Adverse events
- Bupropion (Wellbutrin)“I also couldn't take wellbutrin at all as it just led to a massive ongoing crash a couple days in.” In context ↗ Made symptoms worse