ME/CFS
Severe → no benefit
Mostly in bed with ME/CFS; could not tolerate low-dose naltrexone or bupropion
- Condition
- ME/CFS
- At worst
- Severe (mostly bedbound)
- Ill for
- Not stated
- Last post
- Apr 2026
In their words
- Condition: ME/CFS
GET = avoid at all costs, it will make you worse.
In context ↗ - At worst: Severe
I'm in bed almost all the time and lately it's harder to walk, even though I'm just going to the bathroom or fetching food.
In context ↗ - Now: No benefit
I'm in bed almost all the time and lately it's harder to walk ... I'm too severe to do any type of exercise/physical therapy, no matter how gentle
In context ↗
Read from 11 of their posts and comments; links to the 8 this page draws on
Summary
A Reddit user in r/cfs described being in bed almost all the time and too ill for any exercise or physical therapy, however gentle. They had fainted before and took medication for sleep, and in April 2026 said walking was harder and their feet were curling in. They did not tolerate low-dose naltrexone or bupropion, and an unnamed medication gave them painful acne, so a doctor said to stop it.
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What they tried
Also tried
indica· Helpedsleep medications· No changeSalt in water· WorseLDN· Worsebupropion· WorseEMDR· Not saidInternal Family Systems therapy· Not saidconcentrating on making feet flatter when walking· Not said
Their words about each treatment
- sleep medications · No change
other sleep meds don't work, I've tried them all
In context ↗ - Salt in water · Worse
Salt in water gives me a bad headache but I add it to my food.
In context ↗ - EMDR · Not said
Seconding EMDR, combined with Internal Family Systems therapy.
In context ↗ - indica · Helped
I sometimes smoke indica to sleep.
In context ↗ - LDN · Worse
Gave me nasty, painful acne. Doctor said stop it, was messing with my hormones.
In context ↗ - bupropion · Worse
Unfortunately I didn't tolerate LDN, or bupropion either when I tried it years ago.
In context ↗ - concentrating on making feet flatter when walking · Not said
I'm trying to concentrate on making my feet flatter when I'm walking
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| 2026-03-09 | severe ME/CFS, needing meds for sleep and fainting historyI already take them for sleep (other sleep meds don't work, I've tried them all)In context ↗ | Severe |
| 2026-04-10 | in bed almost all the time, walking became harderI'm in bed almost all the time and lately it's harder to walk, even though I'm just going to the bathroom or fetching food.In context ↗ | Severe |
Adverse events
- Salt, electrolytes and fluids“Salt in water gives me a bad headache but I add it to my food.” In context ↗ Side effects
- Cannabis (THC, marijuana)“I never buy sativa because it makes me very anxious.” In context ↗ Mood or psychiatric effects
- Low-dose naltrexone“Gave me nasty, painful acne. Doctor said stop it, was messing with my hormones.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
I always have to do that during blood draws. I've fainted before.
In context ↗ - Sleep problems
I already take them for sleep (other sleep meds don't work, I've tried them all)
In context ↗