ME/CFS
Somewhat betterNeeds ongoing treatment
Long-standing ME/CFS fatigue and mouth sores, somewhat better after methylfolate
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- Condition: ME/CFS
it doesn't help with my fatigue or anything
In context ↗ - Now: Somewhat better
the fatigue pretty much lingered and slowly improved
In context ↗
Summary
They described long-standing fatigue with mouth sores and low folate that kept their energy down for a long time. They didn't tolerate folic acid well—it made them feel weird—and chose methylfolate; their level rose but recovery was slower than usual, which they blamed on having more than one deficiency. A recent drop in the level meant a big dose increase. A dietary change did not help and initially made them more tired; a dietician advised eating carbs.
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What they tried
Their words about each treatment
- reducing carbs · Worse
I have tried this, and it doesn't help with my fatigue or anything. Initially it made me a lot more tired, actually.
In context ↗ - methylfolate · Helped
Methylfolate does make my level rise and led to a slower than usual recovery for me.
In context ↗ - folic acid · Worse
I don't seem to tolerate folic acid that well. It makes me feel weird.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| — | long-running fatigue with mouth sores and low folatefeeling like shit and having low energy for so long really sucksIn context ↗ |
| over the first few weeks | mouth sores subsided and fatigue slowly improvedThe mouth sore subsided for me over the first few weeks, but the fatigue pretty much lingered and slowly improved.In context ↗ |
| 2026-10-21 | folate level dropped again; much larger methylfolate doseUnfortunately, it recently went way back down and I've had to up my dose of methylfolate by a lot, again!In context ↗ |
Adverse events
- Keto and low-carb diets“Initially it made me a lot more tired, actually.” In context ↗ Made symptoms worse
- Folate / folic acid supplements“I don't seem to tolerate folic acid that well. It makes me feel weird.” In context ↗ Side effects
- Methylfolate (L-methylfolate, 5-MTHF), Folate / folic acid supplements“Methylfolate does make my level rise and led to a slower than usual recovery for me.” In context ↗ Other