ME/CFS
Outcome unclear
ME/CFS and long-standing depression, considering daily dextromethorphan again
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
had no idea it was a PEM buster/preventative!
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A Reddit user with ME/CFS and long-standing chronic depression wrote in 2026 about considering a return to daily dextromethorphan for depression. A few years earlier DXM had left them feeling great, in the same year as ketamine infusions they called a cure for their chronic depression. Auvelity gave no improvement over a few months.
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What they tried
Their words about each treatment
- ketamine infusions · Helped a lot
a round of ketamine infusions, which is truly the cure to chronic depression
In context ↗ - dxm · Helped
I tried it once a few years ago and I felt great, but that was also in the same year after I had a round of ketamine infusions
In context ↗ - Auvelity · No change
I tried Auvelity for a few months which is dxm and Wellbutrin in a pill and I didn't notice any improvements either
In context ↗
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
had no idea it was a PEM buster/preventative!
In context ↗ - Anxiety & low mood
for beating depression vs. the plethora of meds that haven't done shit in 15 years
In context ↗