ME/CFS
No benefitIll for 2 years
ME/CFS crashes, now constant fatigue and headaches, no improvement on lithium or quetiapine
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- 2 years
- Last post
- Feb 2026
In their words
- Condition: ME/CFS
A couple of weeks later, I started developing CFS symptoms
In context ↗ - Now: No benefit
I’ve practically never been symptom-free again (for the past three months)
In context ↗ - Began after: COVID
I probably had COVID at the time, although I was never tested
Read from 5 of their posts and comments; links to the 4 this page draws on
Summary
Alder 13211 dates their CFS to about two years before February 2026, after running and doing HIIT through fatigue and a runny nose, probably with untested COVID. They were mostly symptom-free between crashes until a mood deterioration in November 2025 led to lithium and quetiapine; since then fatigue, headache or low motivation are almost constant. They stopped quetiapine over dizziness and headaches and suspect lithium may be lowering their energy.
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What they tried
Their words about each treatment
- Duloxetine · Worse
I used Duloxetine 30mg and had a mixed episode
In context ↗ - lithium · Not said
I still wonder whether lithium might be dragging my energy down a lot (or it’s just my CFS worsening itself)
In context ↗ - quetiapine · Worse
I managed to stop quetiapine (which gave me a lot of dizziness and headaches)
In context ↗ - an antidepressant · Worse
Another time I took an antidepressant that made me feel wired/with a fast heart rate, and soon after I developed PEM.
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| about 2 years ago (approx. February 2024) | fatigue and runny nose, kept running/HIIT, then CFS symptomsAbout 2 years ago, I was already feeling somewhat fatigued and had a runny nose ... A couple of weeks later, I started developing CFS symptomsIn context ↗ | Mild |
| November 2025 | mood deterioration; started lithium and quetiapine, practically never symptom-free sinceup until November 2025 ... I’ve practically never been symptom-free again (for the past three months)In context ↗ | Mild |
| February 2026 | symptoms most days outside PEM; still on lithiumit’s rare for me not to have some symptom like fatigue, headache, or lack of motivation, even outside of PEMIn context ↗ | Mild |
Adverse events
- Duloxetine (Cymbalta)“I used Duloxetine 30mg and had a mixed episode” In context ↗ Mood or psychiatric effects
- Quetiapine (Seroquel)“I managed to stop quetiapine (which gave me a lot of dizziness and headaches)” In context ↗ Side effects
- Duloxetine (Cymbalta), Antidepressants (unspecified)“Another time I took an antidepressant that made me feel wired/with a fast heart rate, and soon after I developed PEM.” In context ↗ Heart rhythm problems
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
it’s rare for me not to have some symptom like fatigue, headache, or lack of motivation, even outside of PEM
In context ↗ - Headaches & migraine
some symptom like fatigue, headache, or lack of motivation
In context ↗ - Anxiety & low mood
mood problems that had been gradually worsening until a sudden deterioration
In context ↗ - Flu-like symptoms
I was already feeling somewhat fatigued and had a runny nose
In context ↗