ME/CFS
Outcome unclear
ME/CFS crash with migraine and bone-deep exhaustion, on nightly low-dose naltrexone
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Jun 2026
In their words
- Condition: ME/CFS
https://www.reddit.com/r/cfs/comments/1uhdeky/_/ou77px1/
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A Reddit user who takes low-dose naltrexone described a morning LDN experiment as a familiar rollercoaster: a few hours of feeling human before a hard crash. They did the same last year and ended up on the couch with a migraine and bone-deep exhaustion after overdoing things. Splitting doses made everything unpredictable, so they now take a single dose at night, which gives a subtle but consistent benefit.
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What they tried
Also tried
Their words about each treatment
- LDN · Helped
i stick to one dose at night now and the benefit is way more subtle but consistent
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| last year | crashed after overdoing it on a morning LDN dosei did the same thing last year and got way too excited rearranging my whole kitchen, only to end up horizontal on the couch with a migraine and bone-deep exhaustion by 2pmIn context ↗ | Low-dose naltrexone |
| 2026-06-27 | settled on one nightly dose with subtle but consistent benefiti stick to one dose at night now and the benefit is way more subtle but consistentIn context ↗ | Low-dose naltrexone |
Adverse events
- Low-dose naltrexone“splitting doses never worked out for me either. it just made everything more unpredictable” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
got way too excited rearranging my whole kitchen, only to end up horizontal on the couch with a migraine and bone-deep exhaustion by 2pm
In context ↗ - Headaches & migraine
horizontal on the couch with a migraine and bone-deep exhaustion by 2pm
In context ↗