ME/CFS
Outcome unclear
ME/CFS fatigue and POTS, low-dose naltrexone tried for three weeks
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Apr 2026
In their words
- Condition: ME/CFS
I'm actually experiencing something similar right now.
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A person who had taken low-dose naltrexone for three weeks felt a bit less fatigue, after an initial increase in fatigue in the first week. Their POTS symptoms worsened, with higher heart rate and blood pressure spikes and a more reactive nervous system, and heart rate variability fell from about 60 to 50.
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What they tried
Also tried
Their words about each treatment
- LDN · Worse
I've only been on LDN for three weeks. So far I feel a bit less fatigue (after an initial increase in fatigue in week one) but my POTS symptoms have gotten worse
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| week one of LDN | fatigue increased in the first week of LDNafter an initial increase in fatigue in week oneIn context ↗ | Low-dose naltrexone |
| 2026-04-20 | a bit less fatigue but worse POTS on LDNI've only been on LDN for three weeks. So far I feel a bit less fatigue ... but my POTS symptoms have gotten worseIn context ↗ | Low-dose naltrexone |
Adverse events
- Low-dose naltrexone“after an initial increase in fatigue in week one” In context ↗ Made symptoms worse
- Low-dose naltrexone“my POTS symptoms have gotten worse: higher HR and BP spikes” In context ↗ Made symptoms worse
- Low-dose naltrexone“my nervous system feels more reactive” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
my POTS symptoms have gotten worse: higher HR and BP spikes and my nervous system feels more reactive
In context ↗