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ME/CFS Outcome unclear

Long-term insomnia and night waking with ME/CFS; mirtazapine helps sleep but grogginess

Condition
ME/CFS
At worst
Not stated
Ill for
Not stated
Last post
Aug 2026
Read from 1 of their posts and comments; links to the one this page draws on

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Summary

They have long struggled with insomnia and, in recent years, with waking in the middle of the night. They started mirtazapine 7.5 mg at night for depression and said it knocks them out and seems to help them stay asleep, though it can leave them groggy in the morning; biting the tablet in half helped it wear off by morning. They were unsure whether it was helping their depression.

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What they tried

Their words about each treatment
  • mirtazapine · HelpedI do think it has been helping me stay asleep ... The mirtazapine definitely helps. In context ↗

Adverse events

Symptoms mentioned

Their words about their symptoms
  • Sleep problemsI've always struggled more with insomnia than broken sleep In context ↗
  • Anxiety & low moodI recently started mirtazapine (7.5) for depression In context ↗

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Asking aboutBeacon 60122’s story

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