ME/CFS
Outcome unclear
Long-term insomnia and night waking with ME/CFS; mirtazapine helps sleep but grogginess
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Aug 2026
Read from 1 of their posts and comments; links to the one this page draws on
Summary
They have long struggled with insomnia and, in recent years, with waking in the middle of the night. They started mirtazapine 7.5 mg at night for depression and said it knocks them out and seems to help them stay asleep, though it can leave them groggy in the morning; biting the tablet in half helped it wear off by morning. They were unsure whether it was helping their depression.
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What they tried
Also tried
Their words about each treatment
- mirtazapine · Helped
I do think it has been helping me stay asleep ... The mirtazapine definitely helps.
In context ↗
Adverse events
- Mirtazapine (Remeron)“The downside is, it can make me groggy in the morning.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Sleep problems
I've always struggled more with insomnia than broken sleep
In context ↗ - Anxiety & low mood
I recently started mirtazapine (7.5) for depression
In context ↗