ME/CFS
Outcome unclear
ME/CFS with PEM and daytime sleepiness: Amantadine takes edge off, no big PEM change
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Nov 2025
In their words
- Condition: ME/CFS
I haven't noted any drastic changes to my PEM since I've been on it
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
The user has post-exertional malaise and narcolepsy causing daytime sleepiness, and takes 100 mg of Amantadine each morning for the sleepiness. They describe a gentle effect that takes the edge off but no drastic change in PEM, and no negative side effects so far despite being sensitive to all medications. They stopped it for a couple of weeks as a test and restarted it without problems.
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What they tried
Also tried
Their words about each treatment
- Amantadine · Helped
I haven't noted any drastic changes to my PEM since I've been on it ... I'm on 100mg, and I take it in the morning.
In context ↗
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I haven't noted any drastic changes to my PEM since I've been on it
In context ↗ - Sleep problems
daytime sleepiness caused by Narcolepsy
In context ↗