ME/CFS improved somewhat on meds, then relapsed after a Wellbutrin crash
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Jul 2022
In their words
- Condition: ME/CFS
before I even had CFS
In context ↗ - Now: Relapsed
felt great for a few weeks. Then, the biggest crash ever. I lost my husband, I've lost everything.
In context ↗
Read from 5 of their posts and comments; links to the 5 this page draws on
Summary
A Reddit user with CFS had taken spironolactone for years for acne with no effect on their CFS, while a stimulant and a depression medication helped somewhat. Iron supplements lifted ferritin from 7 to 21 without a felt difference. Wellbutrin made them feel great for a few weeks, then brought the biggest crash ever; their husband left and they said their life was ruined.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- Spironolactone · No change
I've been on Spiro for years for acne. Also have EBV markers. Spiro hasn't helped at all unfortunately.
In context ↗ - stimultant · Helped
Getting on a stimultant and depression med has helped some.
In context ↗ - CBT · Helped
I do weekly CBT and while I very much appreciate my therapist's time, the coping mechanisms only do so much.
In context ↗ - iron supplements · No change
After 4 weeks of 3x a day iron supplements I'm up to 21 ... I can't say I feel a difference between 7 and 21
In context ↗ - Wellbutrin (bupropion) · Much worse
I was on it and felt great for a few weeks. Then, the biggest crash ever.
In context ↗
Approaches: Other drugs and medicines · Stimulants
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 2 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | CFS of unstated causeI've been taking it for years for my acne, before I even had CFS.In context ↗ | Not stated | |
| 2022-06-16 | some help from a stimulant and a depression medicationGetting on a stimultant and depression med has helped some.In context ↗ | Not stated | Stimulants (unspecified) |
| 2022-07-20 | biggest crash ever after Wellbutrin; marriage endedI was on it and felt great for a few weeks. Then, the biggest crash ever.In context ↗ | Moderate | |
| 2022-07-20 | still in a dark place after the crashit sent me into a dark place and my life is literally ruinedIn context ↗ | Moderate |
Adverse events
- Bupropion (Wellbutrin)“I was on it and felt great for a few weeks. Then, the biggest crash ever.” In context ↗ Made symptoms worse
- Bupropion (Wellbutrin)“it sent me into a dark place and my life is literally ruined” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I pushed past pacing
In context ↗ - Anxiety & low mood
Getting on a stimultant and depression med has helped some.
In context ↗
Ask Miruvor AI
Similar stories
-
Severe long COVID brain fog, somewhat better with Lamictal and low-histamine diet
A 19-year-old developed long COVID in 2023, with severe brain fog so bad they could not hold a conversation, plus anhedonia, low energy and sexual dysfunction. Antidepressants and psychostimulants steadied their thinking, and Lamictal was the only prescribed…
-
Not enough detail to draw a path
ME/CFS fatigue and depression, somewhat better after vitamin D and ADHD stimulants
Posting in June 2026, the person described fatigue and depression, with low vitamin D. Treating the vitamin D deficiency and the depression took some of the edge off their fatigue, and stimulant medication for their ADHD also helped. An SSRI they tried…
-
Chronic fatigue and brain fog, a little better with medication and bed-based exercises
Hare 25109 has chronic fatigue with brain fog, muscle weakness and insomnia, and was diagnosed with neurally mediated hypotension after six months of testing. They were on medication for blood pressure, heart rate and fluid retention, and a psychiatrist…
-
Bedbound at worst with ME/CFS, now mostly housebound and a little better with pacing and rest
Ill since age 20, they were bed bound at their worst and have since been mostly housebound, slipping between moderate and severe. They credit pacing, rest, hydration, plain food and a low-carb diet with small gains, and a mast cell diagnosis and new…