ME/CFS
Outcome unclear
ME/CFS fatigue unchanged or worse after a year on a drug, severe anhedonia
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Mar 2026
In their words
- Condition: ME/CFS
been on it a year does nothing for my fatigue
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A person in r/cfs took a drug for a year. They said it did nothing for their fatigue and maybe made it worse. They also reported severe anhedonia from the drug, saying nothing evoked emotion and it was awful.
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What they tried
Also tried
Their words about each treatment
- Mounjaro (tirzepatide) · Worse
been on it a year does nothing for my fatigue, maybe makes it worse ... it gives me severe anhedonia
In context ↗
Adverse events
- Tirzepatide (Mounjaro, Zepbound)“been on it a year does nothing for my fatigue, maybe makes it worse” In context ↗ Made symptoms worse
- Tirzepatide (Mounjaro, Zepbound)“it gives me severe anhedonia ... nothing evokes emotions, its awful” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Anxiety & low mood
it gives me severe anhedonia
In context ↗