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Long COVID Severe → no benefitIll for 4 months

Long COVID fatigue and crashes, no improvement after Zyrtec and Pepcid

Condition
Long COVID
At worst
Severe (mostly bedbound)
Ill for
4 months
Last post
Feb 2025
In their words
  • Condition: Long COVIDI’m 28 years old and was severely hit by a viral infection (COVID-19) about 3 months and 3 weeks ago. In context ↗
  • At worst: SevereI can only manage about 30 minutes of being upright before I have to lie down again. In context ↗
  • Now: No benefitDidn’t work on my end either, I would actually say it made things worse!!! My dysautonomia came back, my tachycardia returned. In context ↗
  • Began after: COVIDwas severely hit by a viral infection (COVID-19) In context ↗
Read from 4 of their posts and comments; links to the 3 this page draws on

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Summary

A 28-year-old hit by COVID-19 developed crippling fatigue and crashes; about three months in they could be upright only 30 minutes before needing to lie down again. Increasing walking from 5 to 10 minutes caused a crash that left them still stuck in bed two weeks later. Zyrtec and Pepcid made them feel like a zombie; a treatment they tried made things worse and brought back dysautonomia and tachycardia. No improvement was reported.

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What they tried

Their words about each treatment
  • slowly increasing my activity · Much worseI tried slowly increasing my activity, starting with 5 minutes of walking and working up to 10 minutes. But as soon as I did that, I had a massive crash that felt like catching the flu times 50. In context ↗
  • iron · Not saidI’ve been taking iron under medical advice In context ↗
  • magnesium · Not saidI stopped magnesium and vitamin D after trying them for a while In context ↗
  • Zyrtec · Worsethis antihistamine is making me feel like a zombie! ... Didn’t work on my end either, I would actually say it made things worse!!! My dysautonomia came back, my tachycardia returned.
  • Pepcid · WorseI just started Zyrtec and Pepcid, and I’m on my third day. ... this antihistamine is making me feel like a zombie! In context ↗

Their path

Very severeSevereModerateMildNear normalRecoveredonset3 mo

How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.

Show as a table
WhenWhat happenedWhere they wereAfter
about 3 months and 3 weeks before 2025-01-27hit by COVID-19; crippling post-viral fatiguewas severely hit by a viral infection (COVID-19) In context ↗Severe
2025-01-27stuck in bed after crash from increasing walking from 5 to 10 minutesI can only manage about 30 minutes of being upright before I have to lie down again In context ↗SevereGraded rehab and self-made programmes
2025-02-07antihistamines made things worse; dysautonomia and tachycardia returnedit made things worse!!! My dysautonomia came back, my tachycardia returned In context ↗SevereCetirizine (Zyrtec)

Adverse events

  • Graded rehab and self-made programmes“I tried slowly increasing my activity, starting with 5 minutes of walking and working up to 10 minutes. But as soon as I did that, I had a massive crash that felt like catching the flu times 50.” In context ↗ Made symptoms worse
  • Cetirizine (Zyrtec)“I just started Zyrtec and Pepcid, and I’m on my third day. I’m already severely fatigued, and this antihistamine is making me feel like a zombie!” In context ↗ Side effects
  • Cetirizine (Zyrtec)“I would actually say it made things worse!!! My dysautonomia came back, my tachycardia returned.” In context ↗ Made symptoms worse

Symptoms mentioned

Their words about their symptoms
  • Post-exertional malaiseI had a massive crash that felt like catching the flu times 50 In context ↗
  • POTS & dysautonomiaMy dysautonomia came back In context ↗
  • Heart symptoms & palpitationsmy tachycardia returned In context ↗
  • Sleep problemsEvery morning feels like I’ve been hit by a truck In context ↗
  • Muscle weaknessI can barely move and have to stay in bed for 2 hours stretching just to get enough strength to stand up In context ↗
  • Anxiety & low moodwho wouldn’t feel anxious or frustrated in this situation? In context ↗

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