Moderate to severe ME/CFS, now mostly mild with esketamine
- Condition
- ME/CFS
- At worst
- Severe (mostly bedbound)
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- Condition: ME/CFS
in hindsight, it was mostly moderate/severe ME.
In context ↗ - At worst: Severe
mostly moderate/severe ME
In context ↗ - Now: Much better
I went from moderate/severe to mild/moderate (mostly mild) in a few weeks.
In context ↗
Summary
After years of fatigue put down to severe treatment-resistant depression, Moon 62809 took esketamine (Spravato) and went from moderate/severe ME to mostly mild within a few weeks. A bupropion-dextromethorphan combination had helped but caused awful side effects. The gain held only while dosing at least weekly; going less often brought deterioration. They still relied on pacing aids such as dim lights and earplugs.
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What they tried
What they credit
Also tried
Their words about each treatment
- antidepressants · No change
because I had tried so many antidepressants without any success my psych suggested spravato/esketamine
In context ↗ - bextromethorphan-bupropion · Worse
actually first I tried bextromethorphan-bupropion which is, no joke, bupropion and cough syrup, and while that worked the side effects were awful
In context ↗ - esketamine (spravato) nasal spray · Helped
I went from moderate/severe to mild/moderate (mostly mild) in a few weeks
In context ↗ - accidental aggressive rest · Not said
this could well have been due to other factors, like accidental aggressive rest and a decrease in stress
In context ↗ - protein shakes and supplements · Not said
protein shakes and suppliments bc eating is hard and tiring
In context ↗ - fiber supplement · Helped
having a fiber suppliment helps slow down digestion which can mean fewer bathroom trips which is nice
In context ↗
Approaches: Other drugs and medicines
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| onset | ME/CFS onset; fatigue put down to severe treatment-resistant depressionmy fatigue was attributed to severe treatment resistant depression. in hindsight, it was mostly moderate/severe ME.In context ↗ | Severe | |
| — | went from moderate/severe to mostly mild within a few weeks of esketamineI went from moderate/severe to mild/moderate (mostly mild) in a few weeksIn context ↗ | Mild | Ketamine |
| 2026-10-27 | still mostly mild, managing with pacing aids at homehaving a lot of lamps I can control from bed/the couch helps a lotIn context ↗ | Mild |
Adverse events
- Dextromethorphan-bupropion (Auvelity)“actually first I tried bextromethorphan-bupropion which is, no joke, bupropion and cough syrup, and while that worked the side effects were awful” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Light & noise sensitivity
noise canceling headphones and foam earplugs. often worn at the same time
In context ↗ - Gut problems
having a fiber suppliment helps slow down digestion which can mean fewer bathroom trips which is nice
In context ↗ - Muscle weakness
can you tell my grip strength is bad lol
In context ↗
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