Bone-tired and sleepy with ME/CFS, much better after switching to tirzepatide
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- May 2025
In their words
- Now: Much better
tirzepatide removed my daytime sleepiness and has me feeling like a normal human with the energy i remember having before.
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
A Reddit user on a chronic fatigue forum described daytime sleepiness and a bone-tired feeling. Semaglutide exhausted them worse. Switching to tirzepatide removed the daytime sleepiness and the bone-tired feeling and left them feeling like a normal human with the energy they remembered from before.
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What they tried
What they credit
Also tried
Their words about each treatment
- Semaglutide · Worse
Semaglutide exhausted me worse
In context ↗ - tirzepatide · Helped a lot
tirzepatide removed my daytime sleepiness and has me feeling like a normal human with the energy i remember having before
In context ↗
Approaches: GLP-1 drugs
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | Where they were |
|---|---|---|
| — | chronic fatigue with daytime sleepiness and a bone-tired feelingThat bone tired feeling is gone.In context ↗ | Not stated |
| — | semaglutide made the exhaustion worseSemaglutide exhausted me worseIn context ↗ | Not stated |
| 2025-05-25 | tirzepatide lifted the daytime sleepiness and bone-tirednesstirzepatide removed my daytime sleepiness and has me feeling like a normal human with the energy i remember having before.In context ↗ | Near normal |
Adverse events
- Semaglutide (Ozempic, Wegovy)“Semaglutide exhausted me worse...” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Sleep problems
tirzepatide removed my daytime sleepiness
In context ↗
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