Long COVID fatigue leaving only work and rest, now much better with fexofenadine and LDN
- Condition
- Long COVID
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 2 years
- Last post
- Apr 2026
In their words
- Condition: Long COVID
I got long covid after the second time I got COVID
In context ↗ - At worst: Mild
I was able to keep going to my office job ... But couldn't do literally anything else than that....I would get home and have to lie down until the next morning.
In context ↗ - Now: Much better
2 years in, I'm maybe at 80% of functionality.
In context ↗ - Began after: COVID
I got long covid after the second time I got COVID
In context ↗
Summary
They developed long COVID after a second COVID infection a few months after their first; fatigue left them able to work and nothing else, lying down from getting home until morning. Fexofenadine helped within days, and they now take 180 mg morning and night; cautious physical therapy built their tolerance, and low-dose naltrexone took them from about 65% to 80% of previous functioning. Two years in they work, garden and take short hikes, still budgeting energy and worse with heat.
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What they tried
What they credit
Their words about each treatment
- Paxlovid · Not said
both times I had a very high fever and took Paxlovid
In context ↗ - fexofenadine · Helped a lot
That made a huge difference, enough for me to get my head above water and start phase #2.
In context ↗ - physical therapist-guided cautious increase of activity · Helped
My tolerance got better slowly and I now am able to walk about 3,000-5,000 steps a day most days.
In context ↗ - famotidine · No change
I tried taking famotidine for a bit ... but didn't notice much of a difference so I stopped.
In context ↗ - energy budgeting and lying down flat · Not said
I still budget my energy. ... lying down flat for a couple of hours will let me feel better enough to get back on my feet
In context ↗
Approaches: H1 antihistamines · Physiotherapy and rehab
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. 1 step has no time and sits in story order between the steps around it. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| onset | long COVID after a second COVID infection; could only work and then lie downI got long covid after the second time I got COVID ... I would get home and have to lie down until the next morningIn context ↗ | Mild | |
| 12 mo | started fexofenadineThat made a huge difference, enough for me to get my head above waterIn context ↗ | Mild | Fexofenadine (Allegra) |
| — | physical therapy to cautiously increase activityMy tolerance got better slowly and I now am able to walk about 3,000-5,000 steps a day most days.In context ↗ | Mild | Physical therapy / physiotherapy |
| 2026-04-06 | about 80% of previous functioning, mostly after low-dose naltrexonewhich I would say brought me from about 65% functionality to 80%In context ↗ | Mild |
Symptoms mentioned
Their words about their symptoms
- Temperature regulation
I don't deal as well with heat as I used to.
In context ↗
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