ME/CFS with chronic fatigue and unrefreshing sleep, somewhat better with mouth taping
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- 4 years
- Last post
- Jun 2026
In their words
- Condition: ME/CFS
I have CFS for years myself man.
In context ↗ - Now: Somewhat better
I gave up and taped my mouth, which worked consistently.
In context ↗ - Began after: stress or burnout
I had chronic anxiety due to trauma that started 4 years ago
In context ↗
Read from 8 of their posts and comments; links to the 6 this page draws on
Summary
A young r/cfs poster said they had CFS for years, with intermittent chronic fatigue, unrefreshing sleep of up to 12 hours and chronic anxiety. Trazodone gave some improvement in sleep and fatigue, but tolerance set in and sleep stayed disrupted. In June 2026 they reported that mouth taping worked consistently after a drug combination proved too stimulating, and claimed it fixed their CFS.
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What they tried
What they credit
Also tried
Their words about each treatment
- SSRIs · Worse
When I initially started SSRIs two years ago it actually made me wake up multiple times a night.
In context ↗ - benzos / Alprazolam · Helped
When I took benzos they even calmed down my OCD, obessive thoughts and such.
In context ↗ - Pregabalin · Helped
try pregabalin for CFS. it kinda works for me
In context ↗ - Trazodone · Helped
I sorta improved my chronic fatigue by fixing my sleep with Trazodone ... it only lasts for a while due to drug tolerance
- guafacine · No change
guafacine, propanolol, carvedilol, lemborexant, atomoxetine, trihexyphenidyl, agomelatin which never consistently worked
In context ↗ - propanolol, carvedilol · No change
propanolol, carvedilol, lemborexant, atomoxetine, trihexyphenidyl, agomelatin which never consistently worked
In context ↗ - lemborexant · No change
lemborexant, atomoxetine, trihexyphenidyl, agomelatin which never consistently worked
In context ↗ - atomoxetine · Worse
it was too stimulating and caused dreaming which was tiring
In context ↗ - trihexyphenidyl · Worse
did seem to improve my sleep (no more dry mouth) But it was too stimulating and caused dreaming which was tiring
In context ↗ - agomelatin · No change
trihexyphenidyl, agomelatin which never consistently worked
In context ↗ - GLP injections · No change
GLP injections did not help when I suspected it was simple sleep apnea.
In context ↗ - taping my mouth · Helped a lot
I gave up and taped my mouth, which worked consistently.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| 2022 | Trauma-related chronic anxiety, then intermittent chronic fatigue and unrefreshing sleepI had chronic anxiety due to trauma that started 4 years agoIn context ↗ |
| 2025-04-19 | Trazodone improved sleep and chronic fatigue somewhatI sorta improved my chronic fatigue by fixing my sleep with TrazodoneIn context ↗ |
| 2025-05-28 | Trazodone benefit faded with tolerance; sleep swinging between bad and okit only lasts for a while due to drug toleranceIn context ↗ |
| 2026-06-15 | Mouth taping worked consistently; reported that it fixed their CFSI gave up and taped my mouth, which worked consistently.In context ↗ |
Adverse events
- Antidepressants (unspecified), Trazodone (Desyrel), Agomelatine (Valdoxan)“When I initially started SSRIs two years ago it actually made me wake up multiple times a night. I can only sleep continuously up to 3 hours, such absurd.” In context ↗ Insomnia from treatment
- Atomoxetine (Strattera)“did seem to improve my sleep (no more dry mouth) But it was too stimulating and caused dreaming which was tiring.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Sleep problems
non-refreshing sleep despite sleeping on-time for, sometimes 12hrs a day
In context ↗ - Anxiety & low mood
I had chronic anxiety due to trauma that started 4 years ago
In context ↗
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