ME/CFS
Mild → no benefit
Worsening ME/CFS brain fog and fatigue, no benefit from supplements or peptides
- Condition
- ME/CFS
- At worst
- Mild (working or studying, with limits)
- Ill for
- Not stated
- Last post
- Sep 2026
In their words
- At worst: Mild
still got worse and worse and worse overtime (more brain fog, less sociable etc)
In context ↗ - Now: No benefit
Don't take my experience for anything meaningful (because nothing ever works with me haha)
In context ↗
Read from 10 of their posts and comments; links to the 7 this page draws on
Summary
This user has had ME/CFS with brain fog and fatigue for years, worsening over time despite many supplements and doctor treatments. Through 2026, mitochondrial peptides (SS-31, MOTS-C), NAD and other products brought no benefit, and a recent run of retatrutide was suspected of causing massive fatigue and heavy brain fog. They planned a months-long mitochondrial peptide trial at 5mg or more.
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What they tried
Also tried
keto / low-carb (later just meat and fats)· Helpedweight training with gradual tolerance building· Helpedsupplements after testing· No changeCBD concentrated drops with THC· No changeSS-31· No changeNAD· WorseMOTSC· WorseReta (retatrutide)· WorseLL37· Not said
Their words about each treatment
- supplements after testing · No change
a practitioner would give me these supplements after each testing, done about every 3 months. Didn't help for me.
In context ↗ - CBD concentrated drops with THC · No change
Tried CBD, the concentrated drops. With THC. Did the whole vial. Didn't do anything for me.
In context ↗ - keto / low-carb (later just meat and fats) · Helped
keto diet = better mental clarity, less brain fog ... I eat just meat and fats, twice a day, and I'm never hungry
- weight training with gradual tolerance building · Helped
I’ve found tolerance built throughout the months very efficient. U just start slow, don’t mess urself up, and gradually increase that comfort zone.
In context ↗ - SS-31 · No change
Tried 2-3mg for a few cycles before. Nothing either. ... went to a slow tolerance build of about 1.5mg daily for some time, no avail.
- NAD · Worse
NAD gives me a weird sense of "trapped energy" surely because my mito are so effed up.
In context ↗ - MOTSC · Worse
MOTSC seems to make me more tired.
In context ↗ - LL37 · Not said
already ran a one month cycle of LL37, will run another later
In context ↗ - Reta (retatrutide) · Worse
I'm now suspecting it might be the Reta actually. It can have this effect of draining ppl and I'm still low carb
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| 2022-11-16 | Years of supplements and doctor treatments without benefit, steady worseningI tried a whooooole bunch of things and various doctor treatments for years, and still got worse and worse and worse overtime (more brain fog, less sociable etc).In context ↗ | Mild |
| 2026-06-30 | Doing alright for a while on peptidesI was doing "alright" overall, relatively to my case, for some time with peps.In context ↗ | Mild |
| 2026-06-30 | Massive fatigue and heavy brain fog worsening by the day, suspected retatrutideThen the past couple of weeks, massive fatigue, worsening by the day, very heavy brain fog, and I'm now suspecting it might be the Reta actually.In context ↗ | Moderate |
| 2026-09-28 | SS-31 cycles did nothing; planning a months-long 5mg daily trialTried 2-3mg for a few cycles before. Nothing either. But it wasn't long enough.In context ↗ | Mild |
Adverse events
- NAD+ boosters (NMN, nicotinamide riboside, NADH, ATP)“NAD gives me a weird sense of "trapped energy" surely because my mito are so effed up.” In context ↗ Side effects
- MOTS-c“MOTSC seems to make me more tired.” In context ↗ Made symptoms worse
- Retatrutide“massive fatigue, worsening by the day, very heavy brain fog, and I'm now suspecting it might be the Reta actually.” In context ↗ Made symptoms worse