Long COVID with fatigue, POTS and PEM, somewhat better on tirzepatide
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Sep 2026
In their words
- Condition: Long COVID
I got long covid before the vaccine was available.
In context ↗ - Now: Somewhat better
It has been life changing. I still can get PEM and have to pace, but I have been able to do more
In context ↗ - Began after: COVID
I got long covid before the vaccine was available.
In context ↗
Read from 10 of their posts and comments; links to the 7 this page draws on
Summary
Osprey 67987 got long COVID before vaccines were available, with fatigue, hyperadrenergic POTS, mast cell problems, temperature dysregulation and PEM requiring pacing. A first mRNA vaccine seemed to help, the bivalent one made things worse and Novavax was tolerated fine. Tirzepatide, split-dosed at a lower dose, was called life changing, with better energy and less fatigue, though PEM and the need to pace persisted.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- trizepitide · Helped a lot
Trizepitide has brought me actual rest and energy. It has been life changing.
In context ↗ - guanfacine · Helped
I has helped with my hyperpots and ADHD.
In context ↗ - Mast Cell stabilization · Helped
Guanfacine and Mast Cell stabilization
In context ↗ - magnisium · No change
nothing prunes, hydration and magnisium didn't help for me
In context ↗ - pace · Not said
I still can get PEM and have to pace
In context ↗ - COVID vaccines (first mRNA, bivalent, novavax) · Not said
First mRNA seemed to help. The bivalent seemed to make things worse. I tolerate novavax fine.
In context ↗
Approaches: GLP-1 drugs
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 3 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| 2020 | long COVID onset before vaccines were availableI got long covid before the vaccine was available.In context ↗ | Not stated | |
| — | first mRNA vaccine seemed to helpFirst mRNA seemed to help.In context ↗ | Not stated | |
| — | bivalent vaccine made things worseThe bivalent seemed to make things worse.In context ↗ | Not stated | |
| 2026 | tirzepatide brought rest, energy and less fatigueTrizepitide has brought me actual rest and energy. It has been life changing.In context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
| August 2026 | can do more before PEM but still has to paceIt has increased my energy recovery and while I still have to pace, I can do more before signs of PEM.In context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- Tirzepatide (Mounjaro, Zepbound)“A little bit of constipation, particularly at first and when going up even a small amount.” In context ↗ Gut side effects
- COVID vaccination as treatment“First mRNA seemed to help. The bivalent seemed to make things worse.” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I still can get PEM and have to pace
In context ↗ - POTS & dysautonomia
I have hyper POTS.
In context ↗ - Mast cell (MCAS) & allergies
help with mast cell stabilization
In context ↗ - Temperature regulation
I have had luck helping temp regulation with guanfacine.
In context ↗
Ask Miruvor AI
Similar stories
-
Housebound and mostly in bed with ME/CFS, now much better on rapamycin and low-carb diet
Ill for over a decade, Flint 23355 was at worst housebound and mostly in bed. Over the years she improved, crediting a low-carb, high-fat diet, iron infusions and rapamycin at 4 mg, which helped PEM after a direct 6 mg start caused a massive crash; weekly…
-
Severe, housebound ME/CFS, somewhat better with pacing and low-dose naltrexone
A UK woman ill with ME/CFS for eight years, severe and housebound since 2021 after graded walks left her wheelchair dependent. She credited pacing and low-dose naltrexone with steady gains, and later a low-histamine diet with curing insomnia, migraines,…
-
Long COVID at its worst mostly lying down, now nearly back to normal with Zepbound
Ill with long COVID from July 2024; at worst sleeping or lying down most of the day, barely functioning, with fatigue, PEM, brain fog, palpitations and POTS. Antihistamines and supplements raised energy within a week, and nattokinase, bromelain and curcumin…
-
Long COVID made work impossible, now somewhat better with pacing and GLP-1 drugs
He caught COVID in 2022 during Omicron when his son started daycare and kept getting sicker as daycare infections piled up; symptoms peaked about a year in and work became impossible. He improved after a long COVID clinic helped with management and he…