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ME/CFS Moderate → no benefit

Debilitating fatigue for a year with ME/CFS, no improvement

Condition
ME/CFS
At worst
Moderate (mostly housebound)
Ill for
several years
Last post
Sep 2025
In their words
  • Condition: ME/CFSmy chronic fatigue has been worsening for the past year or so and is often debilitating In context ↗
  • At worst: Moderateoften debilitating, impacting my ability to stay awake during the day In context ↗
  • Now: No benefitmy chronic fatigue has been worsening for the past year or so In context ↗
  • Began after: COVIDSeveral years ago I had Covid twice, pretty severe though not requiring hospitalization ... I’ve speculated if long Covid is also a possibility
Read from 2 of their posts and comments; links to the 2 this page draws on

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Summary

A 26-year-old woman described chronic fatigue that had worsened over the past year and was often debilitating, leaving her struggling to stay awake during the day. Blood work was normal, and she wondered whether long COVID after two severe COVID infections, or her depression, PMDD and autism, explained it. She said Wellbutrin had caused a seizure.

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What they tried

Their words about each treatment
  • meds to help with my depression · Worsetake a few different meds to help with my depression (none of which are alleviating my symptoms.) In context ↗
  • Bupropion (Wellbutrin) · Not saidWellbutrin actually caused the aforementioned seizure :( In context ↗

Their path

They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.

WhenWhat happenedWhere they were
several years before 2025COVID twice, severe but not hospitalisedSeveral years ago I had Covid twice, pretty severe though not requiring hospitalization In context ↗Not stated
2025-09-25chronic fatigue worsening over the past year, often debilitatingmy chronic fatigue has been worsening for the past year or so and is often debilitating, impacting my ability to stay awake during the day In context ↗Mild

Adverse events

Symptoms mentioned

Their words about their symptoms
  • Anxiety & low moodI also suffer from major depression, PMDD, and autism In context ↗

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