ME/CFS
No benefit
Severe gallstones and a crash with ME/CFS, no change from tirzepatide
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Jan 2026
In their words
- Condition: ME/CFS
im on tirzepatide for weight loss and havent noticed any change in my ME, or maybe its gotten slightly worse
In context ↗ - Now: No benefit
havent noticed any change in my ME, or maybe its gotten slightly worse, im not sure but im not feeling better or anything
In context ↗
Read from 4 of their posts and comments; links to the 4 this page draws on
Summary
Ridge 25223, who has ME/CFS, described a severe case of gallstones and inflammation that needed surgery in February 2025, followed by a bad crash. Ox bile and digestive enzyme supplements helped with being sick to their stomach after surgery, and a cold they had caught had cleared by late February 2025. By January 2026, tirzepatide for weight loss had produced no change in their ME, or possibly a slight worsening.
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What they tried
Their words about each treatment
- surgery · Worse
im having bad crash after the surgery
In context ↗ - oxbile · Helped
my partner found oxbile and digestive enzyme supplements which have been really working
In context ↗ - tirzepatide · Not said
im on tirzepatide for weight loss and havent noticed any change in my ME, or maybe its gotten slightly worse, im not sure
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| onset | ME/CFS, onset not describedhavent noticed any change in my MEIn context ↗ | |
| 2025-02-23 | crashed after emergency gallbladder surgeryim having bad crash after the surgeryIn context ↗ | |
| 2025-02-24 | felt better once the cold clearedi am feeling better cause the cold i caught is goneIn context ↗ | |
| 2026-01-21 | on tirzepatide for weight loss, ME unchanged or slightly worsehavent noticed any change in my ME, or maybe its gotten slightly worseIn context ↗ | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- “for me personally im having bad crash after the surgery” In context ↗ Made symptoms worse
- Tirzepatide (Mounjaro, Zepbound)“im on tirzepatide for weight loss and havent noticed any change in my ME, or maybe its gotten slightly worse” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Gut problems
ive been battling ibs for the past half a year
In context ↗ - Brain fog
wait i was brain fog heavily
In context ↗