Long COVID with POTS and breathlessness, somewhat better; tirzepatide helped fatigue
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Sep 2026
In their words
- Condition: Long COVID
I had all these symptoms when I was in my initial flare post covid.
In context ↗ - Now: Somewhat better
I've had a lot of gains but I'm only on .25 ... Tirzepitide has helped me heaps but MICRODOSE
- Began after: COVID
I had all these symptoms when I was in my initial flare post covid.
In context ↗
Read from 11 of their posts and comments; links to the 8 this page draws on
Summary
Sequoia 61229 developed long COVID with hyperadrenergic POTS and breathlessness after a COVID infection. Ice packs and cold water helped their symptoms, ketotifen was too sedating, and of the antihistamines only Zyrtec was tolerable. Microdosing tirzepatide (Mounjaro, 0.25 mg weekly) brought gains in fatigue but not their breathing, with heaviness on injection day. They stayed on it, paying about $290 a pen in Australia.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- Alan Gordon’s The Way Out and Tell Me About Your Pain podcast · Helped
The thing that helped me the most when I was locked in to my over stimulated nervous system was listening to Alan Gordon’s book “The Way Out”
In context ↗ - yoga nidra and breathwork · Helped
doing yoga nidra and breathwork for panic and anxiety
In context ↗ - ice packs, cold water showers and swimming · Helped a lot
I was in the same position as this with hyperadrenergic POTS and I’ve found ice packs on back of neck and abdomen help tremendously
In context ↗ - vagus nerve activation (gargling, humming, 4-4-4 breathing) · Not said
Oh and anything that activates the vagus nerve; gargling water, humming, rub your arms and closed eyelids and ears, deep 4-4-4 breathing.
In context ↗ - oximeter and peak flow monitor · Not said
Using these two tools has reassured me enough not to go to Emergency multiple times
In context ↗ - Ketitofen · Worse
I tried Ketitofen and found it was too strong a tranquiliser for me.
In context ↗ - antihistamines (Zyrtec) · Worse
the antihistamines made me feel even more adrenalised until I found the right one, the only one I could take was Zyrtec
In context ↗ - Shotsy app · Not said
monitoring via the Shotsy app
In context ↗ - Tirzepitide / Mounjaro · Helped
I’ve been microdosing Mounjaro and monitoring via the Shotsy app. I’ve had a lot of gains but I’m only on .25
In context ↗
Approaches: GLP-1 drugs · Brain retraining · Mind-body practices
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | long COVID after a COVID infection, initial flare with many symptomsI had all these symptoms when I was in my initial flare post covid.In context ↗ | |
| 2026-02-17 | fatigue improved on microdosed tirzepatideI’ve seen improvements in my fatigue for sure but not my breathing.In context ↗ | Tirzepatide (Mounjaro, Zepbound) |
| 2026-09-11 | still gaining on microdosed tirzepatideTirzepitide has helped me heaps but MICRODOSEIn context ↗ | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- Ketotifen (Zaditen)“I tried Ketitofen and found it was too strong a tranquiliser for me.” In context ↗ Side effects
- Cetirizine (Zyrtec)“the antihistamines made me feel even more adrenalised until I found the right one, the only one I could take was Zyrtec.” In context ↗ Side effects
- Tirzepatide (Mounjaro, Zepbound)“The day of the injection I feel really heavy. ... I feel a lot of fatigue on shot day but better in the days after.” Side effects
Symptoms mentioned
Their words about their symptoms
- POTS & dysautonomia
I was in the same position as this with hyperadrenergic POTS
In context ↗ - Breathlessness
I’ve seen improvements in my fatigue for sure but not my breathing.
In context ↗ - Temperature regulation
I literally had to put ice packs all over my neck and face everyday. The thing that has stopped it for me is a microdose of Mounjaro weekly (0.25).
In context ↗ - Anxiety & low mood
The thing that helped me the most when I was locked in to my over stimulated nervous system was listening to Alan Gordon’s book
In context ↗
Ask Miruvor AI
Similar stories
-
Debilitated by long COVID with PEM and brain fog, now much better; clonidine helped
A man in his fifties with ME/CFS after COVID in July 2022 had four rough months before a booster brought full recovery, then cycles of relapse and partial recovery. A September 2023 sickness left him debilitated and forced early retirement. PEM, fatigue and…
-
Mild-moderate ME/CFS, bedridden five months, some relief from journalling, now severe again
A Reddit user who developed CFS ten years ago after a chronic infection, at first mild-moderate, largely recovered over two to three years with pacing and meditation. She crashed to severe two years ago, was bedridden about five months, rose to…
-
Housebound and mostly bedbound with ME/CFS, a little better with pacing and rest
Tide 52539 fell ill at 15 in 2012 after severe mono and stayed mild for a decade before declining to moderate; therapy that pushed them through symptoms during long COVID left them severe. By 2026 they were housebound and mostly bedbound. Radical rest,…
-
ME/CFS unable to speak, eat or walk at worst, now somewhat better, crediting supplements
Ill since age 14, they became very severe in mid-2025 after Covid, unable to speak, eat or walk and carried to the restroom. They improved slowly to housebound, able to cook and entertain themselves while nocturnal, with a kidney infection and setbacks from…