Long COVID brain fog, now nearly back to normal with bupropion and Xyzal plus Pepcid
- Condition
- Long COVID
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 3 years
- Last post
- Oct 2026
In their words
- Condition: Long COVID
LC hit me in December 2020, when I was 35.
In context ↗ - At worst: Mild
I *know* I’m so fortunate to be physically able to go into the office 2-3 days a week, but that’s all I do.
In context ↗ - Now: Near normal
I’m physically mostly better after 5.5 years, but I’ll never recover from knowing that almost everyone in my life was very quick to forget me.
In context ↗ - Began after: COVID
LC hit me in December 2020, when I was 35.
In context ↗
Read from 67 of their posts and comments; links to the 26 this page draws on
Summary
Long COVID hit her in December 2020, aged 35, with fatigue, brain fog and anxiety; because her infection was asymptomatic she was not diagnosed until early 2024. Bupropion (Wellbutrin) 300 mg cut her brain fog within a week and let her keep working, and in 2026 Xyzal plus Pepcid AC further improved her executive function. She calls herself physically mostly better after 5.5 years, but not 100%, with some fog remaining.
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What they tried
What they credit
Also tried
Their words about each treatment
- ketamine · No change
Ketamine just failed
In context ↗ - venlafaxine · Not said
I was on venlafaxine pre-LC, then switched to fluoxetine post-LC because my doctors initially thought the SNRI had just stopped working.
In context ↗ - Prozac (fluoxetine) · Helped
The fluoxetine helped my mood & suicidality at a high dose, but didn’t improve my brain fog at all.
In context ↗ - Wellbutrin (bupropion) · Helped a lot
Wellbutrin (bupropion) helped my brain fog enough to save my life. The brain fog is still there, but I’m able to function.
In context ↗ - aripiprazole (Abilify) · Not said
I’m also on fluoxetine & aripiprazole for depression
In context ↗ - gabapentin · Helped
My anxiety went absolutely nuts for a while, and gabapentin helped a ton.
In context ↗ - therapy · Helped
3 therapy sessions got me to say, “fuck it!” and go outside again (also taking meds)
In context ↗ - Adderall · Helped
Adderall helps my energy level the most, but I don’t know if doctors will prescribe it just for fatigue.
In context ↗ - Benicar · No change
Benicar didn’t work, but Edarbi did.
In context ↗ - Edarbi · Helped
The first med didn’t work, but the second med got my BP down to human levels, and my anxiety suddenly became so manageable.
In context ↗ - melatonin · Helped
Melatonin (5 mg) has allowed me to (mostly) sleep through the night.
In context ↗ - high-dose vitamin d · Not said
vitamin b complex, high-dose vitamin d, and melatonin
In context ↗ - baby aspirin · Not said
baby aspirin for stroke prevention
In context ↗ - anti-inflammatory diet · Helped
I’ve been eating a mostly anti-inflammatory diet for a few weeks, including plain whole milk yogurt (& blueberries). It’s helped a little, but nothing significant.
In context ↗ - Kegels · Helped
Kegels have helped a bit, but I still always need a panty liner.
In context ↗ - Xyzal · Helped
I bought some Xyzal & Pepcid ac a few days ago, and I’m actually seeing a difference.
In context ↗ - Claritin · Helped
Taking Claritin & Pepcid AC helps a little.
In context ↗ - COVID vaccination as treatment · Not said
the COVID shot & booster all messed me up for a week or two.
In context ↗
Approaches: H1 antihistamines · H2 blockers · Other antidepressants
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| December 2020 | long COVID began after an asymptomatic COVID infectionLC hit me in December 2020, when I was 35.In context ↗ | Mild |
| August 2023 | two spontaneous near-normal weeksI had 2 FANTASTIC weeks back in August. I reconnected with friends, started to plan a virtual party with them, and took a fucking ballet classIn context ↗ | Near normal |
| August 2023 | the good spell ended and she was ill againThen it went away as suddenly as it came.In context ↗ | Mild |
| January 2024 | cognitive impairment, considering leave and disability, suicidalI was already packing up my apartment in preparation for suicide, so it was worth a shot.In context ↗ | Mild |
| February 2024 | bupropion 300 mg cut her brain fog and she stayed at work150 didn’t do much, but 300 makes SUCH a difference.In context ↗ | Mild |
| May 2026 | Xyzal plus Pepcid AC improved executive functionI bought some Xyzal & Pepcid ac a few days ago, and I’m actually seeing a difference.In context ↗ | Mild |
| September 2026 | physically mostly better; brain fog down about 85% but not 100%I’m physically mostly better after 5.5 yearsIn context ↗ | Near normal |
Adverse events
- Fluoxetine (Prozac)“I got very suicidal starting Prozac and it’s such a horrific feeling.” In context ↗ Suicidal thoughts or attempt
- Fluoxetine (Prozac)“After making things worse for a couple of weeks, Prozac has greatly diminished my suicidal thoughts” In context ↗ Made symptoms worse
- COVID vaccination as treatment“the COVID shot & booster all messed me up for a week or two.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
I still have brain fog, but it’s not nearly as bad.
In context ↗ - Anxiety & low mood
I’ve had severe, chronic depression for 25+ years
In context ↗ - Sleep problems
I still need to sleep 10-14 hours a day
In context ↗ - Heart symptoms & palpitations
anxiety causing my constantly-racing heart
In context ↗ - Muscle weakness
I’m so physically weak & mentally confused all the time
In context ↗
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