ME/CFS
Mild → no benefitIll for 3.5 years
Mild fatigue and brain fog with ME/CFS, no improvement on low-dose naltrexone
- Condition
- ME/CFS
- At worst
- Mild (working or studying, with limits)
- Ill for
- 3.5 years
- Last post
- Jun 2023
In their words
- Condition: ME/CFS
Got the CFS in 2020
In context ↗ - At worst: Mild
I first became (perhaps unrelatedly, or not?) mildly fatigued in November 2019, after going on Sertraline.
In context ↗ - Now: No benefit
Got the CFS in 2020 ... I tried LDN briefly, though experienced greatly increased brain fog.
In context ↗ - Began after: nothing they could name
The exact causes are unclear.
Summary
Crest 73735 became mildly fatigued in November 2019 after starting sertraline, then developed brain fog in early 2020; both gradually reached their current level by late 2020, and they got CFS in 2020. In March 2023 low-dose naltrexone at 1.5 ml caused a bad reaction with greatly increased brain fog, so they stopped and planned a lower-dose retry. By June 2023 they were still demoralised about investigating and trying treatments.
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What they tried
Their words about each treatment
- Sertraline · Worse
I first became (perhaps unrelatedly, or not?) mildly fatigued in November 2019, after going on Sertraline.
In context ↗ - LDN (low-dose naltrexone) · Worse
I started on 1.5ml and had a bad reaction, but hopefully it will go better when I start again from a much reduced dosage tomorrow.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| November 2019 | Mild fatigue began after starting sertralineI first became (perhaps unrelatedly, or not?) mildly fatigued in November 2019In context ↗ |
| February 2020 | Occasional brain fog beganI began to experience occasional brain fog in around February 2020.In context ↗ |
| April/May 2020 | Fatigue and brain fog frequency and severity jumpeda slight jump in frequency and severity of that and the fatigue in April/MayIn context ↗ |
| late 2020 | Fatigue and brain fog reached present levelsboth gradually got to present levels by late 2020-ish.In context ↗ |
| March 2023 | Bad reaction to LDN with greatly increased brain fogI started on 1.5ml and had a bad reactionIn context ↗ |
| June 2023 | Still ill and demoralised, planning lower-dose LDN retryI tried LDN briefly, though experienced greatly increased brain fog.In context ↗ |
Adverse events
- Low-dose naltrexone“I started on 1.5ml and had a bad reaction, but hopefully it will go better when I start again from a much reduced dosage tomorrow.” In context ↗ Side effects
- Sertraline (Zoloft)“In April 2020 I may have had COVID (though it's quite likely the feverish feeling was from Sertraline withdrawal when I ran out of pills for a few days).” In context ↗ Withdrawal problems
- Low-dose naltrexone“I tried LDN briefly, though experienced greatly increased brain fog.” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Brain fog
I tried LDN briefly, though experienced greatly increased brain fog.
In context ↗ - Anxiety & low mood
I am frequently demoralised and disaffected about everything
In context ↗ - Temperature regulation
though it's quite likely the feverish feeling was from Sertraline withdrawal when I ran out of pills for a few days
In context ↗