ME/CFS with brain fog and PEM, somewhat better with antihistamines and less sugar
- Condition
- ME/CFS
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- Condition: ME/CFS
My CFS is from long covid
In context ↗ - At worst: Mild
my current hypothesis is that this combined with boosters are what allow me to improve enough to be semi-functional
In context ↗ - Now: Somewhat better
Not listed here, but microdosing psilocybin is the best thing I've personally found so far. ... My CFS is from long covid, and my current hypothesis is that this combined with boosters are what allow me to improve enough to be semi-functional.
In context ↗ - Began after: COVID
My CFS is from long covid
In context ↗
Read from 12 of their posts and comments; links to the 9 this page draws on
Summary
A Reddit user with ME/CFS after long COVID reported brain fog, gut symptoms, headaches, insomnia and PEM lasting days after intensive exertion. Antihistamines and cutting sugar helped immensely; lion's mane, hydration and less alcohol also helped. Fish oil, zinc, vitamin C and turmeric seemed to worsen things. Microdosing psilocybin, which they called the biggest thing for them, plus cannabis left them clearer-headed at times; they thought psilocybin combined with boosters helped them become semi-functional.
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What they tried
What they credit
Also tried
Their words about each treatment
- Lion's Mane · Helped
I've found that taking Lion's Mane daily helps.
In context ↗ - cutting sugar out of my diet · Helped
Antihistamines, reducing stress, and avoiding sugar have helped immensely.
In context ↗ - staying well hydrated · Helped
I think staying well hydrated and chewing gum whenever I'm feeling it seem to help
In context ↗ - chewing gum · Helped
chewing gum whenever I'm feeling it seem to help
In context ↗ - fish oil · Worse
some of them seem to have been making things worse. In particular fish oil, zinc, vitamin C, and maybe turmeric.
In context ↗ - standard daily multivitamin · Not said
just stick to antihistamines, lion's mane, a standard daily multivitamin, and tylenol & ibuprofen as needed
In context ↗ - tylenol & ibuprofen · Not said
tylenol & ibuprofen as needed
In context ↗ - cutting back on physical activity · Helped
I think the biggest things in managing my symptoms have been cutting back on physical activity
In context ↗ - decongestants · Not said
Lately I've been experimenting with decongestants and antihistamines before and after physical activity, and it might be helping though it's too early to say for sure.
In context ↗ - limiting alcohol · Helped
limiting alcohol help with brain fog
In context ↗ - probiotic supplements · Helped
I've been taking probiotic supplements regularly and those may have helped to curb it, though it's tough to say for sure if they're responsible.
In context ↗ - LDN · Worse
LDN is the only one of these I've tried. Terrible side effects for me, stopped taking before too long.
In context ↗ - microdosing psilocybin · Helped a lot
microdosing psilocybin is the best thing I've personally found so far
In context ↗ - boosters · Helped
this combined with boosters are what allow me to improve enough to be semi-functional
In context ↗ - cannabis · Helped
I swear that microdosing psilocybin and cannabis have helped my long covid & ME/CFS
In context ↗ - melatonin · Helped
Some supplements (melatonin, magnesium glycinate, L tryptophan, lithium orotate) seem to help a little
In context ↗ - Trazodone · Helped
along with one prescription (Trazodone)
In context ↗ - CPAP · Not said
I just started CPAP recently for mild apnea, too, which I'm hoping also helps a little.
In context ↗
Approaches: H1 antihistamines · Diet · Other drugs and medicines · Pacing · Supplements · Vaccination
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 3 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | ME/CFS following long COVIDMy CFS is from long covidIn context ↗ | Not stated | |
| 2022-02-20 | lion's mane, cutting sugar, hydration, gum helped brain fogYMMV but I've found that taking Lion's Mane daily helps.In context ↗ | Not stated | AHCC and medicinal mushrooms (reishi, shiitake, maitake) |
| 2022-05-11 | antihistamines, stress reduction and no sugar helped immenselyAntihistamines, reducing stress, and avoiding sugar have helped immensely.In context ↗ | Not stated | H1 antihistamines (unspecified) |
| 2026-04-29 | psilocybin microdosing plus boosters made them semi-functionalthis combined with boosters are what allow me to improve enough to be semi-functionalIn context ↗ | Mild | |
| 2026-07-13 | a really bad crash; slowly regaining ability to readregaining my ability to sustain enough focus to read over the past months after a really bad crashIn context ↗ | Moderate | |
| 2026-10-21 | clearer-headed the day after microdosing or cannabisI swear that microdosing psilocybin and cannabis have helped my long covid & ME/CFSIn context ↗ | Mild |
Adverse events
- Omega-3 and fish oil“looking back some of them seem to have been making things worse. In particular fish oil, zinc, vitamin C, and maybe turmeric.” In context ↗ Made symptoms worse
- Zinc“looking back some of them seem to have been making things worse. In particular fish oil, zinc, vitamin C, and maybe turmeric.” In context ↗ Made symptoms worse
- Vitamin C“looking back some of them seem to have been making things worse. In particular fish oil, zinc, vitamin C, and maybe turmeric.” In context ↗ Made symptoms worse
- Turmeric / curcumin“In particular fish oil, zinc, vitamin C, and maybe turmeric.” In context ↗ Made symptoms worse
- Low-dose naltrexone“LDN is the only one of these I've tried. Terrible side effects for me, stopped taking before too long.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
chewing gum, staying well-hydrated, and limiting alcohol help with brain fog
In context ↗ - Post-exertional malaise
I seem to get post-exertion symptoms like clockwork
In context ↗ - Gut problems
definitely in my BMs and all things GI related
In context ↗ - Headaches & migraine
I seem to get headaches whenever I eat sugar now
In context ↗ - Sleep problems
There are nights where I feel powerless to get any more than 3-4 hrs. of sleep.
In context ↗
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