ME/CFS with weekend crashes, now much better with low-dose naltrexone
- Condition
- ME/CFS
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 10 years
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
I've had CFS since Jan 2016.
In context ↗ - At worst: Mild
lately, I've been more or less able to work 5 days a week (from my laptop at home) and then crash out on the weekend
In context ↗ - Now: Much better
I'm so much more functional than I was at the beginning.
In context ↗
Read from 10 of their posts and comments; links to the 7 this page draws on
Summary
Ill since January 2016, they could work five days a week from home but crashed every weekend, and in 2023 they suspected an Indian meal plus stress set off a bad flare. Low-dose naltrexone from Harpal Clinic, 4.5 mg sublingual at night, significantly reduced their fatigue and brain fog; supplements and gut triggers also helped. Ten years in they work from home, see friends once or twice a month and call themselves much more functional than the start.
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What they tried
What they credit
Also tried
Their words about each treatment
- working out all of my food intolerances · No change
I spent a couple of years trying to work out all of my food intolerances, but I could never get to a state where I wasn't having gastrointestinal symptoms
In context ↗ - LDN (low dose naltrexone) · Helped a lot
I've found it to be incredibly helpful. ... it seems to significantly reduce my brain fog.
In context ↗ - rest/meditate twice a day · Helped
I try to rest/ meditate twice a day. ... I often don't have time for this, but then I'm shattered all week
In context ↗ - DXM (Robitussin) · Worse
It has made me feel extremely anxious, agitated and distressed! It is quite powerful.
In context ↗ - HRT · Not said
I had mecfs for years before I started HRT. ... I'm still on HRT.
In context ↗ - supplements · Helped
I've found supplements that genuinely help.
In context ↗ - stimulants (including caffeine) · Worse
I've experimented a lot with stimulants and I'm now confident they're a bad idea
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. The chart starts 7.3 years after onset: the story doesn’t say how ill they were before that. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| January 2016 | ME/CFS onsetI've had CFS since Jan 2016.In context ↗ | Not stated | |
| 2023 | able to work five days a week from home, crashing at weekendsI've been more or less able to work 5 days a week (from my laptop at home) and then crash out on the weekend.In context ↗ | Mild | |
| May 2023 | bad flare-up after an Indian meal and stressFrom Friday afternoon until now (Monday) I've been in a really really bad CFS flare-up.In context ↗ | Moderate | |
| October 2024 | LDN reduced their fatigueLDN helps me. ... It's quite effective to be honest.In context ↗ | Mild | Low-dose naltrexone |
| January 2026 | ME/CFS more or less under controlI've got it more or less under control -- i can work from home and I can go out with friends about once or twice a monthIn context ↗ | Mild | Low-dose naltrexone |
| September 2026 | ten years in, more functional than at the start10 years in, still experimenting. It's helping.In context ↗ | Mild | Low-dose naltrexone |
Adverse events
- “Subsequent days I had a bit more, 7.5ml one day and 10ml today. It has made me feel extremely anxious, agitated and distressed!” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I've been more or less able to work 5 days a week (from my laptop at home) and then crash out on the weekend.
In context ↗ - Brain fog
it seems to significantly reduce my brain fog
In context ↗ - Gut problems
I've found out a lot of my gastrointestinal triggers.
In context ↗
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