Long COVID
Mild → somewhat betterIll 3 years before improving or writing
Long COVID with concentration problems, somewhat better off guanfacine and NAC
- Condition
- Long COVID
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 3 years
- Last post
- Jul 2025
In their words
- At worst: Mild
getting upset at work
In context ↗ - Now: Somewhat better
Feel so much better - calm, can get things done, focus.
In context ↗ - Began after: COVID
I’m on yr 3 of LC.
In context ↗
Summary
In the third year of long COVID, they started extended-release guanfacine with NAC and found it like night and day, with better concentration and minimal side effects. After about 6-8 months it stopped helping and they became manic, emotionally dysregulated and anxious, so they stopped everything. They then felt much better, calm, able to get things done and focus, and later said they had stopped after a few months because of unwanted side effects.
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What they tried
Their words about each treatment
- extended release guancafine · Helped
I take one extended release guancafine 1/day with 600mg NAC and take another NAC at night.
In context ↗ - Xanax · Not said
Also, I’m going to fly and usually take Xanax.
In context ↗
Their path
What they say at each step doesn’t fit the worst point or outcome above on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| 2021 (approx.) | long COVID onsetI’m on yr 3 of LC.In context ↗ | |
| 2024-10-27 | guanfacine and NAC helped concentration like night and dayYes! Like night and day. I take one extended release guancafine 1/day with 600mg NAC and take another NAC at night. Minimal side effects. I can concentrate but don’t feel like I’m on speed like Adderal.In context ↗ | Guanfacine |
| 2024-11-15 | guanfacine and NAC stopped helping; became manic, dysregulated and anxiousIt stopped helping and I began to feel manic (talking too fast, too much, hogging conversation), very emotionally dysregulated (aka yelling at my husband, getting upset at work), and anxious.In context ↗ | Guanfacine |
| 2024-11-15 | stopped guanfacine and NAC; felt much betterInstead I stopped everything. Feel so much better - calm, can get things done, focus.In context ↗ |
Adverse events
- Guanfacine“It stopped helping and I began to feel manic (talking too fast, too much, hogging conversation), very emotionally dysregulated (aka yelling at my husband, getting upset at work), and anxious.” In context ↗ Mood or psychiatric effects
- NAC (N-acetylcysteine)“It stopped helping and I began to feel manic (talking too fast, too much, hogging conversation), very emotionally dysregulated (aka yelling at my husband, getting upset at work), and anxious.” In context ↗ Mood or psychiatric effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
I can concentrate but don’t feel like I’m on speed like Adderal.
In context ↗