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ME/CFS Moderate → somewhat better

Moderate ME/CFS and colitis, somewhat better with a GLP-1 drug and oestrogen patches

Condition
ME/CFS
At worst
Moderate (mostly housebound)
Ill before improving or writing
Not stated
Last post
Sep 2026
In their words
  • Condition: ME/CFSI have moderate CFS as well as colitis. In context ↗
  • At worst: ModerateI have moderate CFS as well as colitis. In context ↗
  • Now: Somewhat betterIt has considerably helped my fatigue, joint pain, inflammation and PEM and my colitis flares have decreased. In context ↗
Read from 2 of their posts and comments; links to the 2 this page draws on

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Summary

A patient with moderate CFS and colitis reported that, after 15 months on a GLP-1 drug at 5 mg, their fatigue, joint pain, inflammation and PEM had considerably improved and their colitis flares had decreased. Oestrogen patches also helped and they called the combination great. They joined the Optimum Health clinic, which did not help them personally.

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Asking aboutMeadow 83115’s story

What they tried

Also tried

Their words about each treatment
  • GLP-1 · Helped a lotOn GLP-1 for 15 months. It has considerably helped my fatigue, joint pain, inflammation and PEM In context ↗
  • Oestrogen patches · HelpedOestrogen patches also helped me, the combo has been great. In context ↗
  • digestive enzymes · Not saidThis helps to absorb the nutrients in her view. In context ↗
  • Optimum Health clinic · No changeI joined the Optimum Health clinic, they didn’t help me personally In context ↗
  • eating more healthily · Not saidI just eat more healthily now which must also help. In context ↗

Approaches: GLP-1 drugs · Sex hormones

Their path

Very severeSevereModerateMildNear normalRecovered

How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.

Show as a table
WhenWhat happenedWhere they wereAfter
—Living with moderate CFS and colitisI have moderate CFS as well as colitis In context ↗Moderate
2026-08-3115 months on a GLP-1 drug; fatigue, PEM, joint pain and colitis flares improvedOn GLP-1 for 15 months. It has considerably helped my fatigue, joint pain, inflammation and PEM and my colitis flares have decreased In context ↗ModerateGLP-1 drugs (unspecified)
2026-09-14Joined the Optimum Health clinic, which did not help personallyI joined the Optimum Health clinic, they didn’t help me personally In context ↗Moderate

Symptoms mentioned

Their words about their symptoms
  • Post-exertional malaisehelped my fatigue, joint pain, inflammation and PEM In context ↗
  • Gut problemsmy colitis flares have decreased In context ↗

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Asking aboutMeadow 83115’s story

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