ME/CFS
No benefitIll for 3 years
ME/CFS worsened after antibiotics, pregabalin gave no overall benefit
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- 3 years
- Last post
- Mar 2026
In their words
- Condition: ME/CFS
I’ve had CFS for three years.
In context ↗ - Now: No benefit
I haven’t recovered or improved yet.
In context ↗
Read from 5 of their posts and comments; links to the 4 this page draws on
Summary
Sparrow 60887 had CFS for three years, initially very mild, then worsened in spring 2025 after a course of antibiotics. Intense anxiety led to a new anxiety medication. Pregabalin, taken at 75-100 mg daily, reduced muscle tension and dysautonomia after two to three weeks, helped POTS symptoms with longer-term use, and was associated with less PEM, though sleep problems persisted. They reframed an acute infection and recovered from it relatively quickly.
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What they tried
Also tried
pregabalin· Helpedcourse of antibiotics· Worsenew medication for anxiety· Not saidreframing symptoms as positive signals· Not said
Their words about each treatment
- course of antibiotics · Worse
things got worse this spring after a course of antibiotics
In context ↗ - new medication for anxiety · Not said
my mental state collapsed and I had to start new medication for anxiety
In context ↗ - reframing symptoms as positive signals · Not said
The illness felt less stressful, and I recovered relatively fast.
In context ↗ - pregabalin · Helped
What helped me was taking a lower dose consistently (around 75-100 mg daily), and I only noticed benefits after about 2–3 weeks.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | Where they were |
|---|---|---|
| about 2022 | CFS onset, very mildI’ve had CFS for three years. It used to be very mildIn context ↗ | Mild |
| spring 2025 | worsened after a course of antibioticsthings got worse this spring after a course of antibioticsIn context ↗ | Not stated |
| 2025-11-21 | mental state collapsed; started anxiety medicationmy mental state collapsed and I had to start new medication for anxietyIn context ↗ | Not stated |
| 2026-02-25 | pregabalin reduced muscle tension and dysautonomiareduced muscle tension, fewer neurological symptoms, and a general calming of dysautonomiaIn context ↗ | Not stated |
| 2026-03-05 | still on pregabalin; less PEM, sleep issues persistlower neurological symptoms, less PEMsIn context ↗ | Not stated |
Adverse events
- Antibiotics (unspecified)“It used to be very mild, but things got worse this spring after a course of antibiotics.” In context ↗ Made symptoms worse
Symptoms mentioned
Anxiety & low moodHeadaches & migrainePOTS & dysautonomiaPain & fibromyalgiaPost-exertional malaiseSleep problemsTemperature regulation
Their words about their symptoms
- POTS & dysautonomia
It also helped my POTS symptoms
In context ↗ - Sleep problems
still jave sleep issues
In context ↗ - Pain & fibromyalgia
muscle tension, pain, dysautonomia
In context ↗ - Anxiety & low mood
constant fight-or-flight mode that hasn’t stopped since
In context ↗ - Headaches & migraine
fever, sweating, headaches, and exhaustion
In context ↗ - Temperature regulation
fever, sweating
In context ↗