Unable to work with ME/CFS, now somewhat better on tirzepatide
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- At worst: Moderate
I’m by no means cured, but it’s really the best I’ve felt since I had to quit working.
In context ↗ - Now: Somewhat better
I’m not cured by any means, but a lot more functional.
In context ↗
Summary
Writing in r/cfs, they described ME/CFS that had forced them to quit working, and they kept a shower bench for when they needed to sit. They started low-dose naltrexone and, about two months later, tirzepatide; on tirzepatide their brain fog went from about a third of their old function to two-thirds, with extra fatigue on day three after each shot. Almost six months in they were a lot more functional and less inflamed, though not cured.
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What they tried
What they credit
Their words about each treatment
- LDN · Helped
The rest of the week I feel the best I’ve felt in years between the tirz and having started LDN a couple months before that.
In context ↗ - tirzepatide · Helped a lot
Regular size doses of tirzepatide have done wonders for my brain fog.
In context ↗
Approaches: GLP-1 drugs
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | ill enough with ME/CFS to quit working; kept a shower bench for when they could not standthe best I've felt since I had to quit workingIn context ↗ | Moderate | |
| 2026-08-27 | brain fog improved on tirzepatide plus LDN started a couple months earlierI went from my brain working about 1/3 as well as it used to, to about 2/3 what I used to haveIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
| 2026-10-09 | more functional and less inflamed after almost six months of LDN and tirzepatidedoing better than I have in years ... a lot more functionalIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- Tirzepatide (Mounjaro, Zepbound)“A little extra fatigue on day 3 after my shot, but that’s just likely because day 2 I barely eat.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Brain fog
my brain working about 1/3 as well as it used to, to about 2/3 what I used to have
In context ↗
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