Long COVID fatigue, nearly back to normal with low-histamine diet and antihistamines
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 18 months
- Last post
- Aug 2025
In their words
- Condition: Long COVID
I battled long covid hell for 18 months.
In context ↗ - At worst: Moderate
I battled long covid hell for 18 months. ... I just began to feel 90% normal in the last 6 months
In context ↗ - Now: Near normal
I have been at 95% for over a year now, basically fine.
In context ↗ - Began after: COVID
I'm now dealing with LC since December of 2022 from a second round of Covid.
In context ↗
Read from 21 of their posts and comments; links to the 14 this page draws on
Summary
Long COVID after a second COVID infection in December 2022 left them with fatigue, palpitations, extreme anxiety and histamine intolerance, with gut pain dating from a first infection in 2020. A low-histamine diet with antihistamines, colostrum, lactoferrin, meditation and lymphatic massage brought steady improvement, though lactoferrin first worsened sleep and their nervous system. By 2025 they had been at 95% for over a year but remained sensitive to medication, and in August 2025 they felt unwell again with fatigue and diarrhea, likely COVID.
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What they tried
What they credit
Also tried
Their words about each treatment
- propranolol · Not said
I take propranolol, and usually take CBD but have been limiting it because it seems to lower my BP too much when taken together.
In context ↗ - CBD · Worse
usually take CBD but have been limiting it because it seems to lower my BP too much when taken together.
In context ↗ - low histamine diet · Helped
I've been on a low histamine diet for two weeks ... My symptoms are improving daily
In context ↗ - Quercetin · Helped
along with Quercetin, vitamins, Claritin and Pepcid twice a day
In context ↗ - Claritin / Clarinex · Helped
along with Quercetin, vitamins, Claritin and Pepcid twice a day ... down to one Clarinex a day
- Pepcid · Helped
Actually off the Pepcid (h2 blocker) for a two weeks now
In context ↗ - daily meditations · Helped a lot
mediation has made a huge difference for me ... Daily meditation, sometimes a few times a day, helped settle things down.
In context ↗ - lymphatic drainage massage · Helped
I also do daily meditations and lymphatic drainage massage. My symptoms are improving daily
In context ↗ - Colostrum (Sovereign Labs) · Helped
after 6 weeks on it, I'm very glad I tried it ... The pain has been gone for about a month. I think it's the colostrum that did it.
- manuka honey · Helped
I switched to raw organic honey when I ran out and noticed an increase in reflux and general stomach discomfort. Just started back yesterday and it made a positive difference.
In context ↗ - Chiropractic · Helped
Chiropractic and acupuncture has also been helpful
In context ↗ - lactoferrin · Helped
I started lactoferrin about a week ago and have been feeling worse ... I'm still taking a small dose, 500mg twice a day, but I've seen a big improvement in energy
- DAO enzymes · Not said
I stopped using DAO enzymes before meals a couple months ago. I still take it before something I know is very high histamine like bacon
In context ↗ - NAC · Not said
I've already upped all my supplements and added NAC back in
In context ↗ - time · Helped
takes a combination of diet, supplements, mental health work, and time
In context ↗ - Honey and raw honey · Not said
I switched to raw organic honey when I ran out and noticed an increase in reflux and general stomach discomfort.
In context ↗ - Antibiotics (unspecified) · Not said
Antibiotics for a UTI caused some hives and dizziness this spring.
In context ↗
Approaches: H1 antihistamines · H2 blockers · Alternative therapies · Diet · Mind-body practices · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| 2022-12 | long COVID after a second COVID infectionI'm now dealing with LC since December of 2022 from a second round of Covid.In context ↗ | Moderate | |
| 2023-02-01 | symptoms improving on a low-histamine diet, antihistamines and supplementsMy symptoms are improving daily, but I still have a ways to go.In context ↗ | Mild | Low-histamine diet |
| 2023-04-02 | stomach much better and more energy after colostrumMy stomach feels so much better, and I don't know if it's placebo but my energy has also increased.In context ↗ | Mild | Lactoferrin and colostrum |
| 2023-05-04 | felt worse a week after starting lactoferrinI started lactoferrin about a week ago and have been feeling worse, sleeping problems returned and my nervous system is back on edge.In context ↗ | Mild | |
| 2023-05-18 | early reaction passed and energy improved on lactoferrinI felt kinda crappy for maybe 5-7 days and then it went away ... I've seen a big improvement in energyIn context ↗ | Mild | Lactoferrin and colostrum |
| 2023-10-03 | sitting around 90% of normalI've been sitting around 90% for a while.In context ↗ | Near normal | Lactoferrin and colostrum |
| 2024-05-28 | MCAS/histamine problems 99% better, back to a normal dietI think it's 99% better.In context ↗ | Near normal | |
| 2024-08-15 | sick with COVID-like symptoms, all tests negativeI just began to feel 90% normal in the last 6 months and now I'm sick with something.In context ↗ | Mild | |
| 2025-08-29 | at 95% for over a year, now unwell after husband's positive COVID testBut other than that I have been at 95% for over a year now, basically fine.In context ↗ | Near normal |
Adverse events
- CBD (cannabidiol)“I take propranolol, and usually take CBD but have been limiting it because it seems to lower my BP too much when taken together.” In context ↗ Low blood pressure or fainting
- Lactoferrin and colostrum“I started lactoferrin about a week ago and have been feeling worse, sleeping problems returned and my nervous system is back on edge.” In context ↗ Made symptoms worse
- Honey and raw honey“I switched to raw organic honey when I ran out and noticed an increase in reflux and general stomach discomfort.” In context ↗ Gut side effects
- Antibiotics (unspecified)“Antibiotics for a UTI caused some hives and dizziness this spring.” In context ↗ Allergic reaction / anaphylaxis
Symptoms mentioned
Their words about their symptoms
- Brain fog
My histamine levels are high but not the tryptase (I think that's what it's called/brain fog lol)
In context ↗ - Mast cell (MCAS) & allergies
I had long covid for about a year, including MCAS and histamine issues.
In context ↗ - Sleep problems
sleeping problems returned and my nervous system is back on edge
In context ↗ - Gut problems
Fatigue and diarrhea are the worst complaints so far.
In context ↗ - Heart symptoms & palpitations
heart palpitations, extreme anxiety,and histamine intolerance
In context ↗ - Anxiety & low mood
Covid wrecked my nervous system and my anxiety/stress reaction was out of control.
In context ↗
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