ME/CFS
Severe → no benefit
ME/CFS with brain fog and rolling PEM, bedbound crash after MDMA therapy, still declining
- Condition
- ME/CFS
- At worst
- Severe (mostly bedbound)
- Ill for
- Not stated
- Last post
- Jul 2026
In their words
- At worst: Severe
I’m on the milder end of severe atm
In context ↗ - Now: No benefit
I did MDMA therapy which caused a massive rolling PEM crash, and I since haven’t been able to improve, in fact it’s only been getting worse
In context ↗
Read from 12 of their posts and comments; links to the 8 this page draws on
Summary
Canyon 76939, in Australia, has chronic fatigue along with CPTSD. A three-month clinical MDMA therapy for CPTSD and depression ended in April 2026 and left them more fatigued than ever, followed by a bedbound crash, a partial recovery, and continued decline by July 2026. They described brain fog, rolling PEM, poor sleep, a fast heart rate and depression.
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What they tried
Also tried
Their words about each treatment
- MDMA therapy · Much worse
I just finished a 3 month clinical MDMA therapy for CPTSD and depression, and it was gruelling, I’m the most fatigued I’ve ever been.
In context ↗ - talk therapy sessions · Not said
It was 3 dosing sessions spaced about 3 weeks apart and like 10 talk therapy sessions.
In context ↗ - journaling · No change
I had tried journaling, for quite a while, but it doesn’t work for me.
In context ↗ - antipsychotic/ antidepressants · Not said
I’m also on loads of meds at the moment, and have changed some, it’s difficult to know if that’s causing issues or not.
In context ↗ - Valium · Not said
I’m currently coming off Valium, and I’m having difficulty sleeping and I have a really fast heart rate.
In context ↗ - THC oil · No change
I’ve started THC oil, but that’s not doing a whole lot for me.
In context ↗ - pacing · No change
I have tried to do as little as possible, but I keep on burning myself out
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| 2026-04-24 | finished 3-month clinical MDMA therapy, most fatigued everI just finished a 3 month clinical MDMA therapy for CPTSD and depression, and it was gruelling, I’m the most fatigued I’ve ever been.In context ↗ | Moderate |
| 2026-05-03 | exponential decline, hard to talkfrom being able to walk around, to finding it hard to talk. and it’s getting worse by the hour.In context ↗ | Severe |
| 2026-06-05 | recovered somewhat after the bedbound crash but baseline far lowerwhich caused a very severe crash (bed bound, not able to move much), since then I’ve recovered somewhat (my baseline fatigue is now way higher than it was 5 months ago when I started).In context ↗ | Severe |
| 2026-07-10 | still declining, no improvement since the crashI did MDMA therapy which caused a massive rolling PEM crash, and I since haven’t been able to improve, in fact it’s only been getting worse.In context ↗ | Severe |
Adverse events
- MDMA“I just finished a 3 month clinical MDMA therapy for CPTSD and depression, and it was gruelling, I’m the most fatigued I’ve ever been.” In context ↗ Made symptoms worse
- MDMA“A few months ago I finished clinical MDMA therapy, which caused a very severe crash (bed bound, not able to move much)” In context ↗ Made symptoms worse
- Diazepam (Valium)“I’m currently coming off Valium, and I’m having difficulty sleeping and I have a really fast heart rate.” In context ↗ Withdrawal problems
Symptoms mentioned
Their words about their symptoms
- Brain fog
The brain fog is hindering my ability to go into the feeling that arise
In context ↗ - Post-exertional malaise
I believe it is compounded / rolling PEM, after I did MDMA therapy.
In context ↗ - Anxiety & low mood
my mental health is horrible
In context ↗ - Sleep problems
I get a bad nights sleep and I can’t get out of bed
In context ↗ - Heart symptoms & palpitations
I have a really fast heart rate
In context ↗