Long COVID brain fog, unable to join in life, somewhat better with LDN and tirzepatide
- Condition
- Long COVID
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- Not stated
- Last post
- Oct 2026
In their words
- Condition: Long COVID
r/covidlonghaulers
In context ↗ - At worst: Moderate
It was about 1 months in at 4.5 mgs that I realized I could actually participate in life activities again
In context ↗ - Now: Somewhat better
I can still have trouble finding the right word but I’m functional again ... holy hell my brain fog and fatigue got so much worse
Summary
Orchid 28699 could not take part in life activities until they reached 4.5 mg of LDN, after which they could join in again. When brain fog set in hard in spring 2026, a higher LDN dose plus low-dose tirzepatide had their head working again about six weeks later, though they still hunted for words. Tamoxifen made their brain fog and fatigue much worse, with two more years on it to go.
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What they tried
What they credit
Also tried
Their words about each treatment
- LDN · Helped a lot
It was about 1 months in at 4.5 mgs that I realized I could actually participate in life activities again/
In context ↗ - low-dose tirzepatide · Helped
I started low-dose tirzepatide for the anti-inflammatory effects. It wasn’t over night but at one point 6-weeks later I suddenly realized that my brain was working again
In context ↗ - tamoxifen · Much worse
I’m on the opposite which is tamoxifen and holy hell my brain fog and fatigue got so much worse.
In context ↗
Approaches: GLP-1 drugs
Their path
What they say at each step doesn’t fit the worst point or outcome above on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| — | titrated LDN to 4.5 mg and could take part in life activities againIt was about 1 months in at 4.5 mgs that I realized I could actually participate in life activities again/In context ↗ | Low-dose naltrexone |
| spring 2026 | brain fog set in hardThis spring my brain fog set in hard.In context ↗ | |
| 2026-09-24 | six weeks after a higher LDN dose and low-dose tirzepatide their brain was working again6-weeks later I suddenly realized that my brain was working againIn context ↗ | |
| 2026-10-01 | brain fog and fatigue much worse after starting tamoxifenholy hell my brain fog and fatigue got so much worseIn context ↗ |
Adverse events
- Tamoxifen“I’m on the opposite which is tamoxifen and holy hell my brain fog and fatigue got so much worse.” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Brain fog
I can still have trouble finding the right word but I'm functional again
In context ↗
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