ME/CFS
No benefitIll for 1 year
ME/CFS for a year with fatigue and brain fog, no benefit from LDA or LDN
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- 1 year
- Last post
- Dec 2025
In their words
- Condition: ME/CFS
I am 25 years old and have been suffering from ME/CFS for one year.
In context ↗ - Now: No benefit
After this first dose, it seems my baseline has dropped, so I'm resting without taking anything for now.
In context ↗
Read from 6 of their posts and comments; links to the 4 this page draws on
Summary
A person in Japan who had had ME/CFS for about a year, with almost no treatment options locally, took LDA at 0.25 mg at their own risk. The first dose lifted the fatigue almost instantly and slightly cleared brain fog, but caused tremors and hyperarousal, and two days later their baseline had dropped, so they stopped it for now. Low-dose naltrexone had done little; benzodiazepines were the only thing helping, and they wanted to use them at most weekly.
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What they tried
Also tried
Their words about each treatment
- reusable cold packs · Helped
I use reusable cold packs and place them on my neck. They really help me feel better.
In context ↗ - LDN · No change
LDN didn't do much.
In context ↗ - LDA · Worse
Just 0.25mg of this drug changed me so much.
In context ↗ - benzodiazepines · Helped
Currently, benzodiazepines are the only thing helping me, so I want to find a safer and more effective medication.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| about December 2024 | fell ill with ME/CFSI am 25 years old and have been suffering from ME/CFS for one year.In context ↗ | |
| 2025-12-25 | first 0.25 mg dose of LDA lifted the fatigue instantly, but brought shaking and hyperarousalImmediately after taking it, that hellish fatigue lifted almost instantly. But my body is shaking, and I'm way too alert.In context ↗ | Low-dose Abilify / aripiprazole |
| 2025-12-27 | felt unwell, baseline dropped, stopped LDA to restAfter this first dose, it seems my baseline has dropped, so I'm resting without taking anything for now.In context ↗ |
Adverse events
- Low-dose Abilify / aripiprazole“my body is shaking, and I'm way too alert.” In context ↗ Side effects
- Low-dose Abilify / aripiprazole“After this first dose, it seems my baseline has dropped” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Brain fog
It seems to be working for my brain fog too. My mind feels a bit clearer.
In context ↗ - Temperature regulation
Japan is also extremely hot and humid right now — it feels like a nightmare for those of us with CFS.
In context ↗