Mild ME/CFS for over 10 years, somewhat better on tirzepatide
- Condition
- ME/CFS
- At worst
- Mild (working or studying, with limits)
- Ill before improving or writing
- 10 years
- Last post
- Sep 2026
In their words
- Condition: ME/CFS
It's the first time I've been able to spend so comfortably after suffering from CFS for more than 10 years.
In context ↗ - At worst: Mild
By the way, I think it's mild CFS
In context ↗ - Now: Somewhat better
fatigue in normal times has decreased considerably ... The only thing that bothes me is the worsening of the fog in the brain
In context ↗
Summary
A Japanese person with mild ME/CFS for over 10 years started tirzepatide at 2.5 mg. Within days, fatigue, concentration, sitting and standing tolerance, gut symptoms and sound and light sensitivity improved; they said it was the most comfortable they had felt in years. A new cognitive symptom, a 'delay in thinking', appeared. They planned to try 5 mg, returning to 2.5 mg if cognition worsened.
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What they tried
What they credit
Also tried
Their words about each treatment
- depression medicine · Not said
I also take depression medicine, but I think it was much more effective than increasing the number of antidepressants.
In context ↗ - Tirzepatide · Helped
fatigue in normal times has decreased considerably, mental stability and concentration have increased, and resistance to sitting and standing has increased significantly
In context ↗
Approaches: GLP-1 drugs
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| onset | onset of CFS more than 10 years agoafter suffering from CFS for more than 10 yearsIn context ↗ | Mild | |
| 2026-08-31 | fatigue, concentration, sitting and standing and gut symptoms improved on tirzepatidefatigue in normal times has decreased considerably, mental stability and concentration have increased, and resistance to sitting and standing has increased significantlyIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
| 2026-09-01 | many symptoms better but cognitive symptoms worsened; planned to try 5 mgother parts have improved, but only important cognitive symptoms have worsenedIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
Adverse events
- Tirzepatide (Mounjaro, Zepbound)“Sometimes I feel nauseous, but I don't need to take medicine.” In context ↗ Gut side effects
- Tirzepatide (Mounjaro, Zepbound)“the worsening of the fog in the brain, or rather, the symptoms such as the usual fog of the brain + strange "delay in thinking" are appearing ... This has not been in my cognitive symptoms so far.” In context ↗ Made symptoms worse
- Tirzepatide (Mounjaro, Zepbound)“even though other parts have improved, but only important cognitive symptoms have worsened.” In context ↗ Made symptoms worse
Symptoms mentioned
Their words about their symptoms
- Brain fog
the worsening of the fog in the brain ... "delay in thinking"
In context ↗ - Gut problems
The symptoms of the intestines have also improved considerably.
In context ↗ - Light & noise sensitivity
Endurance has increased in many areas, such as physical, mental, and hypersensitivity to sound and light.
In context ↗ - Post-exertional malaise
I feel like the allowable value of PEM has only increased slightly
In context ↗ - Anxiety & low mood
I also take depression medicine
In context ↗
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