Years of brain fog and fatigue upright, some improvement after medication changes
- Condition
- Condition not stated
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 3 years
- Last post
- Jul 2025
In their words
- Condition: Condition not stated
So maybe this isn’t “true” ME/CFS but some kind of **central dysregulation**
In context ↗ - At worst: Moderate
I feel better in the morning, then gradually deteriorate the longer I stay upright or stimulated.
In context ↗ - Now: Somewhat better
I’m not as unwell as I was three years ago, but I have improved overall since then.
In context ↗ - Says they never had: Headaches & migraine
I don’t get headaches, pain, or heart rate spikes.
- Says they never had: Heart symptoms & palpitations
I don’t get headaches, pain, or heart rate spikes.
- Says they never had: POTS & dysautonomia
I’m *not* diagnosed with POTS — I have no tachycardia, no fainting, no dizziness.
- Says they never had: Pain & fibromyalgia
I don’t get headaches, pain, or heart rate spikes.
Summary
A Reddit user described a disabling condition lasting over three years that began after they stopped long-term Lexapro: brain fog and mental fatigue building while upright, sensory intolerance, and relief only when lying flat. Antidepressants, anxiolytics and mood stabilisers brought no lasting relief. Altered psychiatric medications this year gave slight gains; they said they were less unwell than three years earlier but still not as well as they should be.
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What they tried
Also tried
Their words about each treatment
- Lexapro (SSRI) · Not said
this entire issue began shortly after quit Lexapro (SSRI)
In context ↗ - antidepressants · No change
I’ve tried antidepressants, anxiolytics, and mood stabilizers — no lasting relief
In context ↗ - sleep aids · Not said
including sleep aids, SSRIs, anxiolytics, and antipsychotics
In context ↗ - rest / lying down · Helped
when I lie down, symptoms reduce, sometimes significantly
In context ↗ - deep breathing · Helped
Relief only comes from lying fully flat, especially with deep breathing
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were |
|---|---|---|
| ~2022 (three years before July 2025) | illness began after stopping long-term Lexapro; worst point, not as unwell sincefor me this entire issue began shortly after quit Lexapro (SSRI)In context ↗ | Moderate |
| 2025-07-06 | improved overall but still crashes daily when upright; psychiatric medications altered this year with slight gainsI’m not as unwell as I was three years ago, but I have improved overall since then.In context ↗ | Moderate |
Symptoms mentioned
Their words about their symptoms
- Brain fog
Heavy “brain fog” that worsens with time upright — feels like internal shutdown or derealization
In context ↗ - Post-exertional malaise
I actually *do* experience worsening after mental or physical exertion — but in my case it happens within the same day
In context ↗ - Light & noise sensitivity
Sensory intolerance — noise, lights, conversation feel unbearable
In context ↗ - Anxiety & low mood
Occasional emotional overstimulation when fatigued (like panic or inner pressure)
In context ↗