Mild-to-moderate ME/CFS with PEM and pain; DMT and thiamine helped, then relapsed
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 4 years
- Last post
- Sep 2023
In their words
- Condition: ME/CFS
I discovered the value of N, N-DMT for treating CFS
In context ↗ - At worst: Moderate
I’m mild/ moderate.
In context ↗ - Now: Relapsed
I had a bunch of remissions my first 4 years, like maybe 30% of that time I was in remission. Now it seems less and less likely that I’ll have another one
In context ↗
Read from 10 of their posts and comments; links to the 9 this page draws on
Summary
A person described mild-to-moderate ME/CFS with PEM, chronic pain and depression, ill for over four years with remissions in the first four, now less likely. They credited N,N-DMT with temporary pain relief, clearing PEM and resetting severity from moderate to mild, and later thiamine and B-vitamin/cofactor supplements with feeling better after a week. Cannabis stopped crashes and eased pain but caused tachycardia, and depression if overused.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- methylated B complexes / basic B's · Worse
I have a severe paradoxical reaction to methylated B complexes that includes anhedonia ... I had to stop taking those.
In context ↗ - thiamine (TTFD) · Helped
Good results with TTFD format. ... also I’m benefitting a lot from thiamine
- magnesium, electrolytes (sodium, potassium) · Helped
I just restarted a supplement regimen and this time I’m starting with the basic B’s and cofactors—magnesium, sodium, potassium. Mildly reacting at the beginning but starting to feel pretty good after a week+ in.
In context ↗ - cannabis (weed / THC) · Helped
It can stop an upcoming crash dead in its tracks. I feel better the next day too. ... a couple times of week is amazing.
In context ↗ - healthy diet habits · Helped
Pairing occasional weed use with healthy diet habits is honestly as close to feeling healthy as I can get.
In context ↗ - modafinil · Not said
I haven’t done many, but that includes things like modafinal, adderal, cocaine of course, even coffee and sugar.
In context ↗ - N, N-DMT · Helped a lot
smoking N, N-DMT in a high quality form could do the following for me: ease pain symptoms, rejuvenate me physically and mentally, eliminate post-exertional malaise and reset my severity (from moderate to mild)
In context ↗ - going some place with clean air, low population, elevation · Helped a lot
Geographic location has the biggest impact on my symptom severity. Going some place with clean air, low population, elevation or perhaps some other unknown factor will see me improving within 12 hours.
In context ↗ - ketamine · Helped
It’s pretty nice, like a vacation for your brain (strong anti-inflammatory effects). Long term, it doesn’t seem to have much affect
In context ↗
Approaches: POTS medication · Other drugs and medicines · Supplements
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 1 step says too little to place on the scale and is only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| onset | ME/CFS onset; later remissions in first four yearsI had a bunch of remissions my first 4 yearsIn context ↗ | Not stated | |
| first 4 years | several remissions, about 30% of the first four yearsI had a bunch of remissions my first 4 years, like maybe 30% of that time I was in remissionIn context ↗ | Mild | |
| a few years ago | N,N-DMT eased pain, cleared PEM, reset severity from moderate to mildeliminate post-exertional malaise and reset my severity (from moderate to mild)In context ↗ | Mild | |
| 2023-06-26 | restarted B-vitamin/cofactor regimen; felt pretty good after a weekstarting to feel pretty good after a week+ in.In context ↗ | Mild | Thiamine / benfotiamine |
| 2023-06-30 | cannabis stopped an upcoming crash; felt better next dayIt can stop an upcoming crash dead in its tracks. I feel better the next day too.In context ↗ | Mild | |
| 2023-07-20 | fewer remissions; months without oneNow it seems less and less likely that I’ll have another one as months and months pass without itIn context ↗ | Moderate | |
| 2023-07-26 | still mild/moderate; no recent remissionI’m mild/ moderate.In context ↗ | Moderate |
Adverse events
- Vitamin B complex“I have a severe paradoxical reaction to methylated B complexes that includes anhedonia (I’m very undermethylated)…I had to stop taking those.” In context ↗ Mood or psychiatric effects
- Cannabis (THC, marijuana)“I have to limit my usage of it because I’ll get depressed if I do it too much, but a couple times of week is amazing.” In context ↗ Mood or psychiatric effects
- Cannabis (THC, marijuana)“I’ve seen marijuana give me tachycardia (I was hooked up to medical equipment at the time). I imagine that it must usually do that to me but I like the benefits anyways” In context ↗ Heart rhythm problems
- DMT“I reached the conclusion that the mental effects of smoking DMT are too strong, in general, to warrant frequent use for pain-relief.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
It can stop an upcoming crash dead in its tracks.
In context ↗ - Pain & fibromyalgia
chronic pain relief, mood boost
In context ↗ - Heart symptoms & palpitations
I’ve seen marijuana give me tachycardia
In context ↗ - Anxiety & low mood
I’ll get depressed if I do it too much
In context ↗
Ask Miruvor AI
Similar stories
-
In bed 98% of the time with ME/CFS, improved for a month then relapsed
A US serviceman fell ill around 2015 with fatigue, eye pain, tinnitus and sleep problems, and by 2017 was in bed 98% of the time. Adderall and caffeine carried him until his symptoms worsened; sleep aids, gabapentin and cannabis helped only partly. A bad…
-
Bedridden with ME/CFS for two years, now much better after moving to sea level and pacing
Bedridden with ME/CFS for two years after a June 2020 crash, she improved in January 2025 after moving from Utah to sea level, going from walking 50 feet to miles within a week; she credited the move, years of pacing and POTS drugs. By mid-2025 she continued…
-
Very severe ME/CFS, bedridden and nearly blind, now moderate after pacing and magnesium
Badger 55654 fell ill in 2015 and declined to very severe by June 2020, bedridden and essentially blind from dry eyes and deaf from sound sensitivity. With rigid pacing and radical rest, then magnesium, allithiamine, a cervical collar, saline IVs and POTS…
-
Severe long COVID, now much better after augmented NAC and fibrinolytics
A Reddit user with ME/CFS and long COVID, with fatigue, brain fog, joint pain, unrefreshing sleep and MCAS flares, plus POTS. A high-dose thiamine ramp helped his energy, and a broader stack including pacing, electrolytes and supplements got him from…