ME/CFS with PEM, somewhat better after low-dose naltrexone
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Mar 2025
In their words
- Condition: ME/CFS
noticeable decrease in PEM
In context ↗ - Now: Somewhat better
I could feel a noticeable decrease in PEM, and recovery time from PEM was also shortened.
In context ↗
Summary
A Reddit user with ME/CFS used cannabis edibles daily for over three years to escape mental and emotional pain, and described a mental addiction to them. Low-dose naltrexone, titrated slowly to 2 mg, was the only thing that helped: it noticeably cut PEM and shortened recovery time for about a year, until PEM rose again and a 2.5 mg dose brought improvement back. They also got a handicapped parking permit in Rhode Island, which helped.
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What they tried
What they credit
Also tried
Their words about each treatment
- edibles (cannabis) · Helped
it's not a physical pain reliever, but it allows me to stop focusing on my pain and negativity for a while
In context ↗ - LDN · Helped
When I got to 2 mg, I could feel a noticeable decrease in PEM, and recovery time from PEM was also shortened.
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| 2024-07-16 | ill with ME/CFS; onset date not givenI have been using edibles daily for over 3 years now to escape my mental and emotional pain.In context ↗ | |
| 2024-12-03 | LDN reduced PEM and shortened PEM recovery timeWhen I got to 2 mg, I could feel a noticeable decrease in PEM, and recovery time from PEM was also shortened.In context ↗ | Low-dose naltrexone |
| 2025-03-20 | obtained a handicapped parking permit, found it helpfulIt's been very helpful being able to park close to the door!In context ↗ |
Adverse events
- Cannabis (THC, marijuana)“I very much have a mental addiction to it now. I have wanted to stop due to memory issues and not feeling present in my life, but so far, I haven't been able to.” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Post-exertional malaise
I could feel a noticeable decrease in PEM, and recovery time from PEM was also shortened
In context ↗ - Brain fog
I have wanted to stop due to memory issues and not feeling present in my life
In context ↗
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