Long COVID
No benefitNeeds ongoing treatment
Long COVID neuropathy spreading and worsening despite switching medications
- Condition
- Long COVID
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Sep 2026
In their words
- Condition: Long COVID
r/covidlonghaulers
In context ↗ - Now: No benefit
I am getting worse. Thank you for asking.
In context ↗
Read from 8 of their posts and comments; links to the 8 this page draws on
Summary
A Reddit user in long-COVID forums described neuropathy starting after amlodipine 2.5 mg in May 2025, with tingling, swollen ankles, insomnia, anxiety, tremor and flushing. They switched to ramipril with far fewer side effects, but neuropathy continued and spread to hands, lips and head. White wine with supper eased tingling and insomnia, and clonazepam helped the neuropathy. By late 2026 they said they were getting worse, possibly from diabetes or amlodipine.
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What they tried
Also tried
Ramipril· HelpedWhite wine with supper· HelpedClonazepam· HelpedSleep medication (half of 25 mg tablet)· HelpedAmlodipine· Much worseLyrica· Not saidGabapentin· Not said
Their words about each treatment
- Amlodipine · Much worse
Mostly tingling sensations (paresthesia; neuropathy) and swelling (edema) of ankles, feet, calves ... it was a bad drug for me
In context ↗ - Ramipril · Helped
I now take Ramipril 2.5mg with much much fewer side effects.
In context ↗ - White wine with supper · Helped
a glass of white wine with supper helps tingling and insomnia
In context ↗ - Clonazepam · Helped
I also take 5.mg clonazepam per day which is much better than Lyrica or gabapentin
In context ↗ - Sleep medication (half of 25 mg tablet) · Helped
I take 1/2 of min 25.mg per night for sleep. It is excellent.
In context ↗ - Lyrica · Not said
which is much better than Lyrica or gabapentin
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| May 2025 | neuropathy and leg swelling began after starting amlodipineI was on Amlodipine since May at 2.5mg.In context ↗ |
| 2025-09-25 | switched from amlodipine to ramipril, far fewer side effectsI now take Ramipril 2.5mg with much much fewer side effects.In context ↗ |
| 2026-07-19 | clonazepam eased neuropathyClonazepam helps a lot.In context ↗ |
| 2026-08-22 | getting worseI am getting worse.In context ↗ |
| 2026-09-19 | still worsening despite clonazepamBut I am getting worse possibly diabetes or amlodipine induced or something else.In context ↗ |
Adverse events
- Amlodipine (Norvasc)“I had to switch to Ramipril due to edema and neuropathy issues.” In context ↗ Side effects
- Amlodipine (Norvasc)“Neuropathy continues after stopping Amlodipine.” In context ↗ Nerve pain
- Amlodipine (Norvasc)“Mostly tingling sensations (paresthesia; neuropathy) and swelling (edema) of ankles, feet, calves” In context ↗ Nerve pain
- Amlodipine (Norvasc)“many other symptoms such as insomnia, anxiety, tremor, flushing; it was a bad drug for me;” In context ↗ Side effects
- Amlodipine (Norvasc)“many other symptoms such as insomnia, anxiety, tremor, flushing” In context ↗ Insomnia from treatment
- Amlodipine (Norvasc)“many other symptoms such as insomnia, anxiety, tremor, flushing” In context ↗ Mood or psychiatric effects
- Amlodipine (Norvasc)“Paresthesias mostly feet ankles and hands...started with amlodipine and I think that was the initial cause.” In context ↗ Nerve pain
- Amlodipine (Norvasc)“Not sure of the cause, maybe diabetes but definitely started with amlodipine.” In context ↗ Nerve pain
Symptoms mentioned
Their words about their symptoms
- Neuropathy & tingling
Neuropathy continues after stopping Amlodipine.
In context ↗ - Sleep problems
a glass of wine with supper has helped with related insomnia and tingling
In context ↗ - Anxiety & low mood
many other symptoms such as insomnia, anxiety, tremor, flushing
In context ↗