Inflammation and knee pain in ME/CFS, much better with low-dose naltrexone
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- Not stated
- Last post
- Aug 2026
In their words
- At worst: Moderate
13days to get outta bed
In context ↗ - Now: Much better
LDN now that really works imo. ... My t1 improved greatly
In context ↗
Read from 5 of their posts and comments; links to the 5 this page draws on
Summary
In an ME/CFS forum they describe whole-body inflammation and bone-on-bone knee pain. Low-dose naltrexone, the only pharma they take, lowered inflammation like nothing else and let them clock 15,000 steps. After the first few months, depression kept them in bed 13 days, so they now take it five days on, two off with breaks. ALA and PEA help pain and inflammation; a folic acid product harmed them.
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What they tried
What they credit
Their words about each treatment
- LDN · Helped a lot
It reduces inflammation like no other. ... Then, the depression set in.
In context ↗ - Palmtoyethylalamide aka PEA · Helped
Also ALA, Palmtoyethylalamide aka PEA for pain n inflammation. These work❗
In context ↗ - b9 folic Acid · Worse
I got harmed bcse. The b9 was folic Acid...not suited for my mthfr homozygous snp .
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. 2 steps say too little to place on the scale and are only in the table. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | ME/CFS with inflammation all over the body and bone-on-bone knee paininflammation all over my entire bodyIn context ↗ | Not stated | |
| 2025-01-12 | first months on low-dose naltrexone: inflammation dropped, able to walk 15,000 stepsldn allowed me to clock15000 stepsIn context ↗ | Mild | Low-dose naltrexone |
| 2025-01-12 | depression on LDN, in bed 13 days; switched to 5 days on, 2 offThen, the depression set in ... 13days to get outta bedIn context ↗ | Severe | |
| 2025-01-13 | in a flare while inching the LDN dose up4. mg inching up..I'm in a flair.In context ↗ | Not stated | |
| 2026-07-10 | inflammation much lower on LDN; ALA and PEA for painLDN a immune modulator has lowered my inflammation like no other.In context ↗ | Mild | Low-dose naltrexone |
| 2026-08-28 | still going on 5 days on, 2 off LDN despite bone-on-bone knees and MTHFR-related adjustment problemsWithout LDN NOPE.In context ↗ | Mild | Low-dose naltrexone |
Adverse events
- Low-dose naltrexone“Then, the depression set in.❗ ... 13days to get outta bed.” In context ↗ Mood or psychiatric effects
- Folate / folic acid supplements“I got harmed bcse. The b9 was folic Acid...” In context ↗ Other
Symptoms mentioned
Their words about their symptoms
- Pain & fibromyalgia
My bone in bone knees, thru wanted to skip for joy.
In context ↗ - Anxiety & low mood
Then, the depression set in
In context ↗
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