ME/CFS
Severe → no benefit
Bedbound some days with ME/CFS, no improvement on Mounjaro
- Condition
- ME/CFS
- At worst
- Severe (mostly bedbound)
- Ill for
- Not stated
- Last post
- Apr 2025
In their words
- Condition: ME/CFS
I have severe ME/CFS and fibromyalgia.
In context ↗ - At worst: Severe
I have severe ME/CFS and fibromyalgia.
In context ↗ - Now: No benefit
but it's week 4 and I'm still mostly in bed
In context ↗
Read from 1 of their posts and comments; links to the one this page draws on
Summary
Gull 57093 had severe ME/CFS and fibromyalgia, bedbound on some days despite Adderall for energy. Four weeks before writing they started Mounjaro 2.5 mg and said it brought them to their knees; by week four they were still mostly in bed. Their chronic constipation flared and they had yet to hear when it might improve.
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What they tried
Also tried
Their words about each treatment
- Adderall · Helped
I'm on Adderall for energy. Some days it works, other days, I'm bedbound.
In context ↗ - Mounjaro · Much worse
I started Mounjaro 2.5 4 weeks ago. It's brought me to my knees. The 2nd and 3rd weeks were the worst, but it's week 4 and I'm still mostly in bed.
In context ↗ - lubiprostone · Not said
my chronic constipation has flared up. I'm on lubiprostone 16mg daily, but I need to have that increased.
In context ↗ - vitamins · Not said
I take vitamins by the hands full
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, in the order they describe; they don’t give enough times to place each step. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| — | severe ME/CFS and fibromyalgia, bedbound on some daysI have severe ME/CFS and fibromyalgia.In context ↗ | Severe | |
| 4 weeks before 2025-04-04 | started Mounjaro 2.5 mg and was brought to their kneesI started Mounjaro 2.5 4 weeks ago. It's brought me to my knees.In context ↗ | Severe | Tirzepatide (Mounjaro, Zepbound) |
| 2025-04-04 | week 4 of Mounjaro, still mostly in bedit's week 4 and I'm still mostly in bedIn context ↗ | Severe |
Adverse events
- Tirzepatide (Mounjaro, Zepbound)“It's brought me to my knees. The 2nd and 3rd weeks were the worst, but it's week 4 and I'm still mostly in bed.” In context ↗ Made symptoms worse
- Tirzepatide (Mounjaro, Zepbound)“Also, my chronic constipation has flared up.” In context ↗ Gut side effects
Symptoms mentioned
Their words about their symptoms
- Pain & fibromyalgia
I have severe ME/CFS and fibromyalgia.
In context ↗ - Gut problems
my chronic constipation has flared up
In context ↗