ME/CFS fatigue, much worse after stopping a GLP-1, somewhat better after restarting
- Condition
- ME/CFS
- At worst
- Moderate (mostly housebound)
- Ill before improving or writing
- 1 year
- Last post
- Oct 2026
In their words
- Condition: ME/CFS
I finally realized I probably have ME and got diagnosed in May
In context ↗ - At worst: Moderate
I don’t need more energy if I can’t do anything anyways!
In context ↗ - Now: Somewhat better
I’m back on it for two months now and HRV is better and fatigue has lessened. I’m not back to where I was before I stopped
In context ↗
Read from 9 of their posts and comments; links to the 5 this page draws on
Summary
They date their ME/CFS to becoming ill while travelling in October; a decline led to diagnosis in May. Atomoxetine, taken before they knew they had ME, made them extremely fatigued; they were weaning off. They stopped their weight-loss GLP-1 over cost and got much worse; after restarting, HRV improved and fatigue lessened, though not back to their previous level. A multivitamin appeared to trigger peripheral neuropathy, which cleared on stopping.
Ask Miruvor AI
What they tried
What they credit
Also tried
Their words about each treatment
- strattera · Worse
When I started strattera, and when I increased my dose last year, I definitely became extremely fatigued. It passed.
In context ↗ - my watch data · Helped
My watch data has been so helpful in accepting reality and pacing instead of always trying to push myself.
In context ↗ - GLP1 · Helped
I’m back on it for two months now and HRV is better and fatigue has lessened.
In context ↗ - multivitamin · Worse
I started getting peripheral neuropathy suddenly and after research, stopped taking my multivitamin and almost instantly it went away.
In context ↗ - flow charting out the thoughts ... practice the new thought pattern · Helped
My experience is that I can reprogram my response to negative thoughts over time, and sometimes the bad thoughts even stop all together.
In context ↗
Approaches: GLP-1 drugs · Pacing
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| October | became ill while travellinggetting ill from traveling in October and that setting off a downfall in healthIn context ↗ |
| winter | got much worse over the winter after stopping GLP-1 for costI stopped due to cost last September. I got much worse over the winter.In context ↗ |
| June 2026 | restarted GLP-1; HRV improved and fatigue lessenedI’m back on it for two months now and HRV is better and fatigue has lessened.In context ↗ |
| 2026-08-08 | still below their level before stopping the GLP-1I’m not back to where I was before I stopped, and there have been other factorsIn context ↗ |
Adverse events
- Atomoxetine (Strattera)“When I started strattera, and when I increased my dose last year, I definitely became extremely fatigued.” In context ↗ Made symptoms worse
- Multivitamins (Centrum)“I started getting peripheral neuropathy suddenly and after research, stopped taking my multivitamin and almost instantly it went away.” In context ↗ Nerve pain
Symptoms mentioned
Their words about their symptoms
- Neuropathy & tingling
I started getting peripheral neuropathy suddenly and after research, stopped taking my multivitamin and almost instantly it went away.
In context ↗ - Mast cell (MCAS) & allergies
Still dealing with hives a lot tho.
In context ↗ - Anxiety & low mood
I spend some time identifying the thought that triggers bad feelings
In context ↗
Ask Miruvor AI
Similar stories
-
Severe ME/CFS, housebound and often bedbound; walking better after physio, then relapsed
Pebble 29054, in the UK, has suspected ME/CFS and describes a decline from mild to severe after NHS GET/CBT and exercise, now housebound and often bedbound with crashes, sleep disruption, headaches, dizziness, GI/IBS and electrolyte problems. A private…
-
Mostly housebound with ME/CFS, now somewhat better with pacing and medication changes
Hare 62088 fell ill in early September 2010 with a spreading itchy rash and brain fog, later becoming mostly housebound with PEM, IBS and pain while working through crashes. They worked through a knee-injury crash for about a year until being laid off, then…
-
Not enough detail to draw a path
Mostly bedbound with ME/CFS, now somewhat better and mostly housebound after L-carnitine
Summit 98220 fell ill around 2017 and, after years of pushing through work, was mostly bedbound by late 2022, unable to tolerate light or sound. Prescription L-carnitine lifted them from bedbound to moving about the house; low-dose naltrexone and pacing…
-
Mostly housebound with ME/CFS, now much better after pacing and LDN
They fell ill after a Covid infection in 2023 and were mostly housebound a couple of years ago, struggling to hold 15 hours a week of work from home. Diligent pacing brought a stable level, and they now work 22 hours a week from home, walk up to 5 km and…