ME/CFS
Outcome unclear
ME/CFS with pain, tried Lyrica, LDN and Vipassana with mixed effects
- Condition
- ME/CFS
- At worst
- Not stated
- Ill for
- Not stated
- Last post
- Oct 2025
In their words
- Condition: ME/CFS
It has helped me greatly (gave me both literal physical improvement as well as a healthier attitude towards the loss caused by chronic illness)
In context ↗
Read from 5 of their posts and comments; links to the 5 this page draws on
Summary
A person with ME/CFS tried several medications. Lyrica made things much worse immediately and they stopped it quickly; a medication badly worsened their cognition and left a high-adrenaline feeling, which they linked to a slow MAO-A variant found via a consumer DNA test. Low-dose naltrexone suited them better but did little for their pain. A ten-day Vipassana meditation course gave real physical improvement.
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What they tried
Also tried
Their words about each treatment
- Lyrica · Much worse
but tried the Lyrica for a short while too. Terrible stuff, immediately made things much worse for me.
In context ↗ - LD-Naltrexone · Helped
Now started on LD-Naltrexone ... LDN seems to work better with me.
- Escitalopram · Much worse
It made me much worse cognitively (complete loss of focus, high adrenalin feeling) so I didn't try it for long.
In context ↗ - Vipassana 10 day meditation course · Helped
It has helped me greatly (gave me both literal physical improvement as well as a healthier attitude towards the loss caused by chronic illness) ... a "Vipassana" 10 day deep-dive meditation course made a real difference for me.
In context ↗ - Vitamin D · Not said
My sweet spot is 2000 IU/day for a while to solve deficiency.
In context ↗ - quercetin · Worse
This for example helped me to avoid quercetin, a substance in various healthy foods & supplements, which in my case caused nervousness
In context ↗
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened | After |
|---|---|---|
| 2025-07-18 | Lyrica made things much worse; stopped it quicklyTerrible stuff, immediately made things much worse for me. Lucky I got off it quicklyIn context ↗ | |
| 2025-07-23 | escitalopram worsened cognition and focusIt made me much worse cognitively (complete loss of focus, high adrenalin feeling) so I didn't try it for long.In context ↗ | |
| 2025-07-23 | started low-dose naltrexoneLDN seems to work better with me.In context ↗ | Low-dose naltrexone |
| 2025-08-29 | ten-day Vipassana meditation coursegave me both literal physical improvement as well as a healthier attitude towards the loss caused by chronic illnessIn context ↗ | Meditation, yoga, breathwork |
| 2025-10-29 | latest post, on vitamin D dosing and testingMy sweet spot is 2000 IU/day for a while to solve deficiency.In context ↗ |
Adverse events
- Pregabalin (Lyrica)“tried the Lyrica for a short while too. Terrible stuff, immediately made things much worse for me” In context ↗ Made symptoms worse
- Escitalopram (Lexapro)“It made me much worse cognitively (complete loss of focus, high adrenalin feeling) so I didn't try it for long” In context ↗ Made symptoms worse
- Baicalein and quercetin“which in my case caused nervousness as it blocked my already slow COMT enzyme from breaking down adrenaline” In context ↗ Side effects
Symptoms mentioned
Their words about their symptoms
- Pain & fibromyalgia
unfortunately it doesn't do much for pain issues
In context ↗