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Long COVID No benefit

Long COVID with near-constant fatigue and PEM; treatments tried, no overall improvement

Condition
Long COVID
At worst
Not stated
Ill for
Not stated
Last post
Jun 2026
In their words
  • Condition: Long COVIDBut the PEM and near constant fatigue is my biggest issue In context ↗
  • Now: No benefitYup. Rest, don't rest, it didn't seem to make much difference in my case! In context ↗
Read from 2 of their posts and comments; links to the 2 this page draws on

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Summary

A Reddit user in r/covidlonghaulers described long COVID with post-exertional malaise and near-constant fatigue as their biggest problem, plus cognitive issues that were clearing. They listed antihistamines, LDN, Trintellix, low-dose Abilify and Adderall for ADHD, saying the ADHD drug helped somewhat. They said that resting or not resting made little difference in their case.

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What they tried

Their words about each treatment
  • H1 antihistamines · HelpedAntihistamines—both H1 & H2 ... clearing up cognitive issues In context ↗
  • LDN · HelpedLDN ... clearing up cognitive issues In context ↗
  • Trintellix · HelpedTrintellix ... clearing up cognitive issues In context ↗
  • Low dose Abilify · HelpedLow dose Abilify ... clearing up cognitive issues In context ↗
  • Adderrall · HelpedAdderrall for my ADHD helps some. In context ↗
  • Rest · No changeRest, don't rest, it didn't seem to make much difference in my case! In context ↗

Symptoms mentioned

Their words about their symptoms
  • Post-exertional malaisethe PEM and near constant fatigue is my biggest issue In context ↗
  • Brain fogclearing up cognitive issues has made me more acutely aware of all that I don’t have the energy for In context ↗

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