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Immunomodulators

68 people credit immunomodulators as one reason they got better overall (42 with ME/CFS, 26 with long COVID).

Everyone · 213 people

All 213 who tried one of its treatments

How it went for everyone who tried one of its treatments

Helped means they said it helped with what they took it for, which may be one symptom and not the illness. Each person counts once: someone who tried several of these treatments is split equally across those they said how it went for.

60%
helped
102 of 171
14%
no change
25 of 171
26%
got worse
44 of 171

Shares are out of the 171 people who said how it went for at least one of them, each counted once, the parts rounded to whole people. 42 more tried one or credit the approach without saying how it went.

Show as a table
How it wentPeopleShare
Helped a lot3521%
Helped6739%
No change2514%
Worse3722%
Much worse74%

Everyone · 68 people

68 who credit it

Among the 68 who credit it with their improvement, here’s how they are now

Credit it means they say it’s one reason they got better.

25%
recovered or near normal
17 of 67
63%
much or somewhat better
42 of 67
12%
relapsed
8 of 67
1
outcome unclear
not in the shares

Where each person was at the end of their story, or in their latest post that says how they are, compared with their worst point. Shares are out of the 67 people with a clear outcome; 1 more doesn’t say how they are.

Show as a table
Outcome describedPeopleShare
Recovered57%
Near normal1218%
Much better2030%
Somewhat better2233%
Relapsed812%
Outcome unclear1—

Did it last?

  • 6 of 68 said the benefit of a treatment in this approach wore off (5 of them among the 8 who relapsed).
  • 29 of 68 say they still need to keep doing something (not always one in this approach) to stay well.

Read from what people wrote, and the more someone wrote, the more likely they are to mention it. Some people stop posting before saying, so the real number may be higher.

68 who credit it

By how ill people were

Only the 68 who credit this approach, so people it didn’t help or made worse aren’t here. How they are now is their outcome overall.

Severity at worstHow they are nownRecovered or near normal
Mild922%, few people
Moderate1225%
Severe2227%
Very severe1100%, few people
Not stated2422%
Show as a table
At worstOutcomePeopleShare
MildNear normal2 of 922%
MildMuch better1 of 911%
MildSomewhat better5 of 956%
MildRelapsed1 of 911%
ModerateRecovered1 of 128%
ModerateNear normal2 of 1217%
ModerateMuch better5 of 1241%
ModerateSomewhat better2 of 1217%
ModerateRelapsed2 of 1217%
SevereRecovered2 of 229%
SevereNear normal4 of 2218%
SevereMuch better9 of 2241%
SevereSomewhat better5 of 2223%
SevereRelapsed2 of 229%
Very severeRecovered1 of 1100%
Not statedRecovered1 of 234%
Not statedNear normal4 of 2318%
Not statedMuch better5 of 2322%
Not statedSomewhat better10 of 2343%
Not statedRelapsed3 of 2313%

Treatments in this approach

Bar: how it went for everyone on the site who tried it and said so. Recovered and Faded: of the people here who credit it.

The bar (How it went) and the line under each name are among everyone on the site who tried it and said how it went, the same numbers as on each treatment’s own page. Recovered and Faded are among the people here who credit it. Grey numbers rest on fewer than 10 people; a faded share in red is a third or more.

Fewer than 3 people here credit these, so they aren’t ranked: Azathioprine (Imuran), Apremilast (Otezla), Leflunomide (Arava), Mycophenolate (CellCept).

Everyone · 68 people

20 of the 68 people

See all 68 stories
  • Bedbound at worst with ME/CFS after COVID, now somewhat better with pacing

    Somewhat better Vale 94777 ME/CFS Severe at worstIll 4 years before improving or writing reddit.com Oct 2026

    A person in New Zealand became ill with COVID around mid-2022. They worsened for 14 months to severe and bedbound, and are not working. Pacing, an electric wheelchair, mast-cell and arthritis drugs, and vitamin D later brought them to mild (moderate side of…

  • Bedridden with long COVID, near symptomless on IL-2 then relapsed again

    Relapsed Prairie 76226 Long COVID Severe at worst reddit.com Oct 2026

    Prairie 76226 developed long COVID and became completely disabled and bedridden, too ill to see a doctor for over a year. Low-dose interleukin-2 brought them back to almost symptomless within about two weeks to a month, but months later they relapsed and…

  • ME/CFS, brain fog and POTS after COVID; much better, credits naltrexone, aripiprazole

    Much better Cedar 24599 ME/CFS Moderate at worstIll 6 years before improving or writing reddit.com Oct 2026

    COVID in March 2020 led to ME/CFS, brain fog, POTS and fatigue; they worked lying down and could not watch TV. A methylprednisolone taper helped night sweats and sound sensitivity, while aripiprazole, low-dose naltrexone and oral ketotifen cleared the brain…

  • Severe ME/CFS with POTS, now somewhat better after cervical traction and Mestinon

    Somewhat better Flint 57557 ME/CFS Severe at worst reddit.com Oct 2026

    Gradual ME/CFS onset around puberty; neck instability in their mid-20s left them severe with hyperadrenergic POTS, mast cell disease and gastroparesis. Cervical traction and PT took them from severe to moderate, and with Mestinon from worse-end moderate to…

  • Bedbound with long COVID, now much better after two doses of Anktiva

    Much better Ridge 59905 Long COVID Severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    Ridge 59905 got COVID in 2020 and was mildly ill for four years until a crash after returning to the gym left them bedbound. A Giardia infection and a further crash from December 2025 worsened things. Two doses of Anktiva in a summer 2026 trial resolved…

  • Almost bedbound with ME/CFS, now much better after surgery and Mestinon

    Much better Flint 51427 ME/CFS Severe at worst reddit.com Oct 2026

    A Reddit user with an ME-like illness, endometriosis, MCAS, chronic migraine and orthostatic intolerance was almost bed bound before they understood these conditions. Gentle exercise and swimming, then endometriosis surgery abroad and Mestinon, improved…

  • Long COVID unable to stand at the stove, much better on prednisone and cyclosporine

    Much better Swan 23737 Long COVID Severe at worstIll 9 months before improving or writing reddit.com Oct 2026

    Swan 23737, in Portugal, fell ill with COVID in September 2022 and could not stand at the stove or stay at the table without lying down. Prednisone and cyclosporine, given for autoimmune hair loss, greatly improved her energy and cognition, though by late…

  • Long COVID for about two years, now near normal after methotrexate

    Near normal Trail 11388 Long COVID Ill 2 years before improving or writing reddit.com Sep 2026

    A Dutch long COVID patient, ill for about two years after a COVID infection, said an SSRI and diazepam helped a lot, but later could not stop the SSRI and had withdrawal. Methotrexate, taken for uveitis, coincided with roughly 90% recovery. A mild…

  • Severe pleurisy and pleural effusions from long COVID, nearly normal on prednisone

    Near normal Pond 86038 Long COVID Mild at worstIll 3 years before improving or writing reddit.com Sep 2026

    A first COVID infection in 2022 caused severe pleurisy and bilateral pleural effusions, permanently costing about a third of their lung capacity. A long prednisone course followed by ongoing methotrexate injections controlled the inflammation, and they were…

  • Long COVID worsened POTS, dysautonomia and insomnia; prednisone helped, then relapse

    Relapsed Bramble 49777 Long COVID Moderate at worst reddit.com Sep 2026

    After COVID worsened existing POTS, dysautonomia and insomnia and added neurological symptoms, Bramble 49777 got dramatic improvement from prednisone in autonomic, brain and sleep symptoms, though most of it faded. Azathioprine had helped POTS before COVID…

  • Long COVID with severe cognitive impairment, now much better after exercise and RA drugs

    Much better Spruce 70217 Long COVID Severe at worstIll 6 years before improving or writing reddit.com Aug 2026

    Caught COVID-19 in February 2020 and spent the first year with severe cognitive impairment, breathlessness, palpitations and dizziness, barely able to walk across a room. Very gradual daily incremental exercise, B12, sleep, fluids and salt took them to about…

  • Long COVID after severe COVID, much better at 70% of baseline on low-dose naltrexone

    Much better Harbor 99841 Long COVID Moderate at worstIll 6.5 years before improving or writing reddit.com Jul 2026

    Harbor 99841 fell ill with severe COVID in March 2020 and never fully recovered; a second infection in August 2023 and a combined flu/COVID shot in 2024 each worsened their symptoms. Low-dose naltrexone lifted them from moderate to mild, and probiotics,…

  • Long COVID, unable to do anything at first, now about 70% better after inosine pranobex

    Much better Flint 87280 Long COVID Severe at worstIll 18 months before improving or writing reddit.com Jul 2026

    Flint 87280 fell ill with long COVID in January 2023 and could not do anything at first, slowly reaching six hours of home work a day. Inosine pranobex, started about 1.5 years in, cleared their physical PEM within two weeks and lifted them to roughly 70%…

  • Unlivable ME/CFS, now somewhat better on hydroxychloroquine

    Somewhat better Spruce 70214 ME/CFS reddit.com Jul 2026

    A person with ME/CFS said their quality of life had become unlivable before treatment. Sulfasalazine helped greatly, but an incredibly rare heart side effect forced them to look for other options. Hydroxychloroquine from their primary care doctor brought…

  • Six months in bed with long COVID, somewhat better after methotrexate and elimination diet

    Somewhat better Lake 70330 Long COVID Severe at worstIll 3.5 years before improving or writing reddit.com Jul 2026

    After a Covid infection, this user developed long COVID six months later and spent six months in bed with tachycardia, insomnia, chest pain and no appetite, losing 15 kg. Acyclovir with iron and vitamin D, then an elimination diet, gave partial gains. IV…

  • Unable to work or leave the house with long COVID, partly better after metformin and LDN

    Somewhat better Swan 12591 Long COVID Severe at worstIll 4 years before improving or writing reddit.com Apr 2026

    Swan 12591 developed long COVID and interstitial cystitis 30 days after a second Moderna shot in early 2022. She became unable to work or leave the house, and a COVID infection nine months later amplified symptoms and set recovery back six months. Metformin,…

  • Long COVID with T cell depletion and exhaustion, somewhat better with immunotherapy

    Somewhat better Crane 65000 Long COVID reddit.com Jan 2026

    A Reddit user in r/covidlonghaulers reported long COVID with extreme T cell depletion and exhaustion on testing. One treatment did nothing, and metformin and rapamycin destroyed them. They credited immunotherapy with keeping them from remaining sick and…

  • Long COVID with gut problems and fainting, improved on valacyclovir then relapsed

    Relapsed Cardinal 30068 Long COVID Mild at worstIll 3.5 years before improving or writing reddit.com Jan 2026

    Cardinal 30068 developed long COVID around 2022, with gut problems and SIBO, brain fog and later dizziness and fainting. A naturopath diagnosed long COVID and SIBO and prescribed valacyclovir for borderline varicella titres, which helped immensely at first.…

  • Long COVID fatigue and breathlessness, nearly back to normal with nicotine and diet

    Near normal Kite 84036 Long COVID Mild at worstIll 9 months before improving or writing reddit.com Dec 2025

    After long COVID they had fatigue, pain, breathlessness and memory problems, and a five-minute run in January 2025 put them in the ER. Neonatal bovine thymus concentrate, a whole-food diet, nicotine, ivermectin and supplements brought back steady energy over…

  • Long COVID brain fog, seizures and aphasia somewhat better after sulfasalazine

    Somewhat better Oak 34018 Long COVID Ill 2 years before improving or writing reddit.com Aug 2025

    A 21-year-old who caught COVID at 19 developed brain fog and temporal lobe seizures about six months later, and also had aphasia, along with rashes, gut problems and joint inflammation. A rheumatologist found ongoing inflammation and after three months on…

The newest 20 people who credit immunomodulators.

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New recovery stories and data-driven research on ME/CFS and long COVID. Ideas worth considering, and the evidence behind them.

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