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SSRIs

886 people credit SSRIs as one reason they got better overall (210 with ME/CFS, 672 with long COVID, 4 (few people) not stated).

Everyone · 3,908 people

All 3,908 who tried one of its treatments

How it went for everyone who tried one of its treatments

Helped means they said it helped with what they took it for, which may be one symptom and not the illness. Each person counts once: someone who tried several of these treatments is split equally across those they said how it went for.

57%
helped
1,852 of 3,242
11%
no change
342 of 3,242
32%
got worse
1,048 of 3,242

Shares are out of the 3,242 people who said how it went for at least one of them, each counted once, the parts rounded to whole people. 666 more tried one or credit the approach without saying how it went.

Show as a table
How it wentPeopleShare
Helped a lot41213%
Helped1,44044%
No change34211%
Worse88727%
Much worse1615%

Everyone · 886 people

886 who credit it

Among the 886 who credit it with their improvement, here’s how they are now

Credit it means they say it’s one reason they got better.

28%
recovered or near normal
246 of 885
59%
much or somewhat better
525 of 885
13%
relapsed
114 of 885
1
outcome unclear
not in the shares

Where each person was at the end of their story, or in their latest post that says how they are, compared with their worst point. Shares are out of the 885 people with a clear outcome; 1 more doesn’t say how they are.

Show as a table
Outcome describedPeopleShare
Recovered769%
Near normal17019%
Much better25929%
Somewhat better26630%
Relapsed11413%
Outcome unclear1—

Did it last?

  • 67 of 886 said the benefit of a treatment in this approach wore off (38 of them among the 114 who relapsed).
  • 367 of 886 say they still need to keep doing something (not always one in this approach) to stay well.

Read from what people wrote, and the more someone wrote, the more likely they are to mention it. Some people stop posting before saying, so the real number may be higher.

886 who credit it

By how ill people were

Only the 886 who credit this approach, so people it didn’t help or made worse aren’t here. How they are now is their outcome overall.

Severity at worstHow they are nownRecovered or near normal
Mild17342%
Moderate24528%
Severe26425%
Very severe3714%
Not stated16722%
Show as a table
At worstOutcomePeopleShare
MildRecovered19 of 17311%
MildNear normal53 of 17331%
MildMuch better27 of 17315%
MildSomewhat better57 of 17333%
MildRelapsed17 of 17310%
ModerateRecovered20 of 2458%
ModerateNear normal48 of 24520%
ModerateMuch better81 of 24533%
ModerateSomewhat better66 of 24527%
ModerateRelapsed30 of 24512%
SevereRecovered19 of 2647%
SevereNear normal46 of 26418%
SevereMuch better108 of 26441%
SevereSomewhat better50 of 26419%
SevereRelapsed41 of 26415%
Very severeRecovered2 of 376%
Very severeNear normal3 of 378%
Very severeMuch better17 of 3746%
Very severeSomewhat better10 of 3727%
Very severeRelapsed5 of 3713%
Not statedRecovered16 of 16610%
Not statedNear normal20 of 16612%
Not statedMuch better26 of 16616%
Not statedSomewhat better83 of 16650%
Not statedRelapsed21 of 16612%

Treatments in this approach

Bar: how it went for everyone on the site who tried it and said so. Recovered and Faded: of the people here who credit it.

The bar (How it went) and the line under each name are among everyone on the site who tried it and said how it went, the same numbers as on each treatment’s own page. Recovered and Faded are among the people here who credit it. Grey numbers rest on fewer than 10 people; a faded share in red is a third or more.

Everyone · 886 people

20 of the 886 people

See all 886 stories
  • Bedridden for years with ME/CFS, now housebound and moderate after time and rest

    Somewhat better Glacier 44961 ME/CFS Severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    A person with ME/CFS for six or more years was severe and bedridden for several years, then gradually improved to housebound and moderate. They credited time, rest and harm reduction rather than one treatment. Nicotine patches, microdosed psilocybin, pacing…

  • Housebound with long COVID, now much better and back at work after rest and acupuncture

    Much better Spruce 30711 Long COVID Severe at worstIll 2.5 years before improving or writing reddit.com Oct 2026

    An Australian academic in their forties got long COVID in May 2024 after a third infection: brain fog first, then crippling fatigue that left them housebound and crashing daily for months. Rest, time and treatments including acupuncture greatly improved…

  • Very severe, bedridden ME/CFS, now somewhat better with LDN and ketotifen

    Somewhat better Marsh 16925 ME/CFS Very severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    Marsh 16925 fell ill with COVID in 2020 and was diagnosed with ME/CFS and POTS in 2021, becoming very severe, bedridden and near IV nutrition. They credited LDN, ketotifen and other antihistamines, a low-histamine diet, mitochondrial supplements and later…

  • Long COVID 80% recovered with LDN, then a workout crash left them housebound

    Relapsed Zephyr 10189 Long COVID Severe at worstIll 19 months before improving or writing reddit.com Oct 2026

    Zephyr 10189 fell ill with long COVID in early 2022. By 19 months they were about 80% recovered, crediting LDN, antihistamines and gut treatments. A 20-minute leg workout, reported in June 2024, caused a crash with heavy, cramping limbs; by August 2024 they…

  • Long COVID brain fog and fatigue, improved then relapsed after overdoing walks

    Relapsed Glade 30034 Long COVID Moderate at worst reddit.com Oct 2026

    Tested positive January 2022 (Omicron), unable to drive or do much for about three months with brain fog, fatigue, blurred vision and temperature sensitivity, improving to about 85 percent by month five. Overdoing walks in heat caused relapses; a mid-2023…

  • Bedbound with ME/CFS after COVID, some improvement with low-dose naltrexone and ivabradine

    Somewhat better Crocus 16327 ME/CFS Severe at worstIll 15 years before improving or writing reddit.com Oct 2026

    She had 15 years of gradual ME/CFS symptoms with teenage EBV and crashes during her PhD, then became bedbound after COVID in early 2024. Diagnosed with ME/CFS, POTS, MCAS and hEDS in 2025, she credits low-dose naltrexone, ivabradine, H1/H2 antihistamines and…

  • Badly affected by long COVID for months, now nearly back to normal with time and LDN

    Near normal Wave 20769 Long COVID Moderate at worstIll 4 months before improving or writing reddit.com Oct 2026

    They fell ill with COVID in December 2024 and were badly affected for months, taking three months off work on medical leave with brain fog, DPDR, lost smell and numbness. Gradual improvement came with time, PEA with luteolin, LDN, HIIT with oxygen and…

  • Bedbound with ME/CFS, now walking a few miles a day after sertraline

    Much better Moon 97425 ME/CFS Very severe at worst reddit.com Oct 2026

    Posting in 2026, they described constant pain, tension, fatigue, poor concentration and difficulty sleeping, and had earlier been bedbound, unable to walk to the toilet, shower, read or talk. Diagnosed with generalised anxiety and somatoform disorder, they…

  • Housebound with ME/CFS, weeks near normal with fluvoxamine and love, then relapsed

    Relapsed Petrel 52587 ME/CFS Ill 3 years before improving or writing reddit.com Oct 2026

    A man in his late 30s dates his illness to April 2023, when a two-hour subway ride during benzo tapering and a rapid NAC withdrawal left him with severe sensory and cognitive intolerance. He is housebound and can read or watch TV only briefly, with PEM and…

  • Bedbound up to 16 hours a day with long COVID, now much better with pacing and diet

    Much better Mesa 11607 Long COVID Severe at worstIll 3 years before improving or writing reddit.com Oct 2026

    A UK person fell ill with long COVID after a COVID infection in November 2023 and became bedbound up to 16 hours a day for months after quitting smoking. Radical rest and pacing, a low-carb Mediterranean diet with meat reintroduced, fluoxetine and medical…

  • Bedbound with ME/CFS after a two-day CPET, much better with MCAS treatment and pacing

    Much better Tide 69091 ME/CFS Very severe at worstIll 3.5 years before improving or writing reddit.com Oct 2026

    A woman in the Netherlands with ME/CFS became bedbound after a two-day CPET in November 2022. LDN, Mestinon and amitriptyline made her worse and she stopped them. Later MCAS treatment (quercetin, cromolyn, antihistamines), escitalopram and pacing helped; by…

  • Housebound with ME/CFS, somewhat better after testosterone gel

    Somewhat better Ocean 17929 ME/CFS Moderate at worstIll 2 years before improving or writing reddit.com Oct 2026

    A trans man ill with ME/CFS and POTS since about December 2019, he was housebound and mostly sitting up in bed before testosterone gel in February 2022 lifted his energy within a week. Ketotifen and celecoxib also raised his crash threshold. After a…

  • Long COVID with burning limbs and brain fog; Lexapro helped some, then relapse

    Relapsed Flint 35175 Long COVID reddit.com Oct 2026

    A 26-year-old developed long COVID after a fourth infection in July 2024, with heavy burning limbs, brain fog and eye sensitivity, and described it as mild overall. Lexapro eased anxiety and heart symptoms, but by three months they were still having…

  • Daily fatigue and PEM with ME/CFS, somewhat better with Prozac and less work stress

    Somewhat better Stream 75770 ME/CFS Mild at worstIll 5 years before improving or writing reddit.com Oct 2026

    Stream 75770 developed mild long COVID after a suspected infection in March 2020 and was close to normal by mid-2021. Moderna shots brought back daily fatigue, PEM, joint and nerve pain, worse than the first bout. Later they tried Prozac, cut out caffeine…

  • Years of crashing with ME/CFS, now somewhat better with sertraline and pacing

    Somewhat better Lagoon 16755 ME/CFS Severe at worstIll 25 years before improving or writing reddit.com Oct 2026

    A UK woman fell ill at 16 in 2001 after undiagnosed pneumonia and was treated as depressed until a CFS diagnosis at 26, after years of pushing through and crashing. Sertraline helped her energy and careful pacing keeps her at a moderate baseline at 41:…

  • Mostly bedbound with ME/CFS, sertraline helped then a crash left her mostly bedbound again

    Relapsed Otter 65110 ME/CFS Severe at worstIll 3 years before improving or writing reddit.com Oct 2026

    A UK woman ill since 2023, when COVID infections and EBV at 18 left her mostly bedbound for months. Sertraline in early 2024 gave a massive improvement; she was mild, paced and went out every few days. The benefit faded and a November 2025 crash left her…

  • Long COVID brain fog, panic and histamine intolerance, much better with Zoloft and diet

    Much better Moon 18770 Long COVID Moderate at worstIll 2 years before improving or writing reddit.com Oct 2026

    Moon 18770 caught COVID in January 2022; a month later came derealisation-type brain fog, panic, suicidal depression and histamine intolerance. Zoloft 50 mg, time and a strict low-histamine diet are what they credit; HBOT and cold showers did nothing, while…

  • Barely able to leave the house with long COVID, now about 90% after Lexapro and therapy

    Near normal Oak 83835 Long COVID Severe at worstIll 2 years before improving or writing reddit.com Oct 2026

    Long COVID began the day after their first Pfizer dose in 2021 and worsened with later jabs and a second COVID infection in June 2022, with peak symptoms in summer 2022 when they could barely leave the house. They credit doubling Lexapro to 20 mg, adding…

  • Bedbound with ME/CFS for over three years, now somewhat better with time and rest

    Somewhat better Harbor 64407 ME/CFS Very severe at worstIll 3 years before improving or writing reddit.com Oct 2026

    He had ME/CFS from his teens and could no longer work after switching from brand Zoloft to generic sertraline in 2004-05. A J&J COVID vaccination in 2021 left him severe and bedbound for over three years, barely able to manage basic care or think. From about…

  • Long COVID: fluvoxamine helped somewhat, but relapses left them bedridden

    Relapsed Hawk 75141 Long COVID Severe at worstIll 6 years before improving or writing reddit.com Oct 2026

    A US patient ill with long COVID since spring 2020 cycled through relapses, some leaving them bedridden, often after colds and reinfections. Of about 20 treatments, fluvoxamine helped somewhat, easing flu-like symptoms, brain fog and derealisation, though…

The newest 20 people who credit SSRIs.

A little hope, every Sunday

New recovery stories and data-driven research on ME/CFS and long COVID. Ideas worth considering, and the evidence behind them.

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