Long COVID with fatigue and brain fog, somewhat better on tirzepatide
- Condition
- Long COVID
- At worst
- Not stated
- Ill before improving or writing
- 2 years
- Last post
- Aug 2026
In their words
- Condition: Long COVID
with long covid for like 2 years now
In context ↗ - Now: Somewhat better
and the brain fog is noticeably better. not gone but like 40% improvement. energy is still trash but at least i can think clearly enough to work.
In context ↗ - Began after: COVID
with long covid for like 2 years now
In context ↗
Summary
Island 49525 had long COVID for about two years with fatigue, brain fog and joint pain, and had tried LDN, antihistamines, pacing and supplements with only slight benefit. About three weeks before posting they started tirzepatide for weight gain from being so sedentary and possible anti-inflammatory effect; brain fog improved by roughly 40% while energy stayed poor. In a later comment they said they had been on it about six weeks, with fatigue up and down, and wondered whether insomnia could be a side effect after reading someone else's comment.
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What they tried
Also tried
Their words about each treatment
- LDN · Helped
trying everything - LDN, antihistamines, pacing, supplements. some stuff helped a little but nothingmoved the needle.
In context ↗ - tirzepatide · Helped
started tirzepatide about 3 weeks ago ... and the brain fog is noticeably better. not gone but like 40% improvement
In context ↗
Their path
How ill they were on the ME/CFS severity scale, estimated from what they describe at each point, with time counted from when the illness began. Hover or tap a point. Dates are when they posted. What the levels mean.
Show as a table
| When | What happened | Where they were | After |
|---|---|---|---|
| 2024 | long COVID onsetwith long covid for like 2 years now. fatigue, brain fog, joint pain, the whole packageIn context ↗ | Mild | |
| 2026-08-22 | brain fog about 40% better on tirzepatidestarted tirzepatide about 3 weeks ago ... the brain fog is noticeably better. not gone but like 40% improvementIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
| 2026-08-23 | six weeks on tirzepatide, fatigue up and downI started on 0.5mg and have been on it about 6 weeks now. The fatigue thing worries me because mine has been up and down tooIn context ↗ | Mild | Tirzepatide (Mounjaro, Zepbound) |
Symptoms mentioned
Their words about their symptoms
- Brain fog
the brain fog is noticeably better. not gone but like 40% improvement
In context ↗ - Pain & fibromyalgia
fatigue, brain fog, joint pain, the whole package
In context ↗ - Sleep problems
The insomnia thing is interesting though, I hadn't connected that as a possible side effect until reading your comment
In context ↗