ME/CFS physical capacity more than doubled on SS-31; somewhat better with LL-37 added
- Condition
- ME/CFS
- At worst
- Not stated
- Ill before improving or writing
- Not stated
- Last post
- Sep 2026
In their words
- Now: Somewhat better
SS-31 more than doubled my physical capacity around 1-2 weeks in ... I think I have more energy than last time I was taking SS-31.
Read from 6 of their posts and comments; links to the 5 this page draws on
Summary
A US Reddit user with ME/CFS who took the peptide SS-31 after other peptides gave little benefit. Physical capacity more than doubled within one to two weeks, and they became more mentally alert. They stopped after four months because of cost and injections, and their capacity fell, so they resumed SS-31 and added LL-37, which they thought was helping. They had spent around a thousand dollars on peptides.
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What they tried
What they credit
Also tried
Their words about each treatment
- SS-31 · Helped a lot
SS-31 more than doubled my physical capacity around 1-2 weeks in
In context ↗ - MOTS-C · No change
Haven't noticed a change with MOTS-C.
In context ↗ - LL-37 · Helped
I think I have more energy than last time I was taking SS-31. I think it's likely the LL-37 is helping.
In context ↗ - a bunch of different peptides · No change
I tried a bunch of different peptides and haven't experienced any negative side effects from any of them, but also none of them helped me much besides SS-31.
In context ↗
Approaches: Peptides
Their path
They say too little about how ill they were at each step to draw it on the severity scale, so the steps are listed as they describe them. Dates are when they posted.
| When | What happened |
|---|---|
| — | ME/CFS baseline before peptide treatment, capacity limitedSS-31 more than doubled my physical capacity around 1-2 weeks inIn context ↗ |
| 2026-06-03 | physical capacity more than doubled on SS-31, then plateauedSS-31 more than doubled my physical capacity around 1-2 weeks in but I have not progressed any additional amount since then.In context ↗ |
| 2026-08-15 | more mentally alert and greater physical capacity on SS-31Yes, SS-31 makes me much more mentally alert and increases my physical capacity.In context ↗ |
| 2026-08-17 | stopped SS-31 after four months; mental and physical capacity reducedI used SS-31 for four months but stopped because it's expensive and I don't like jabbing myself. But my mental and physical capacity is reduced now so I'm going back on it.In context ↗ |
| 2026-09-11 | resumed SS-31 and started LL-37; more energy than the previous SS-31 courseI think I have more energy than last time I was taking SS-31. I think it's likely the LL-37 is helping.In context ↗ |
Symptoms mentioned
Their words about their symptoms
- Brain fog
my mental and physical capacity is reduced now
In context ↗
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